NIH Principles and Practices of Clinical Research (IPPCR) Final Exam.pdf file:///C:/Users/HP/Desktop/New%20folder/NIH%20Principles%20a
NIH Principles and Practices of Clinical Research
(IPPCR) Final Exam
1. Imhotep
Answer Egyptian, first physician figure to rise out of antiquity; known scribe, priest, architect,
astronomer and magician. performed surgery, practiced some dentistry, extracted medicine
from plants and knew the position and function of vital organs.
2. Hippocrates
Answer Father of modern medicine; Hipprocratic oath --> high moral stan- dards.
3. Which of the following is most likely a case series study?
Answer Report of 5 cases of pneumocytosis pneumonia in previously healthy homosexual men
4. Scientific misconduct can cause which of the following?
Answer All of the above
5. What is/are the reason(s) that NIH requires the inclusion of women and
minorities in all clinical research?
Answer All of the above
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,NIH Principles and Practices of Clinical Research (IPPCR) Final Exam.pdf file:///C:/Users/HP/Desktop/New%20folder/NIH%20Principles%20a
6. What can change a study's power and how power is impacted?
Answer Variation in outcome (Ã2 )p
ower decreases as an outcome's variance increases
7. A for-cause audit conducted by the Food and Drug Administration is best described as
Answer
An audit performed to investigate possible fraud or misconduct
8. The use of common data elements (CDEs) should meet all of the following objectives
EXCEPT
Answer
To promote unneeded or redundant data collection
9. True or False
Answer Tests of general cognitive function, such as IQ tests and mini-mental status
exams (MMSE), provide effective tools for determining whether individuals can give
informed consent for a clinical trial.
Answer False
10. An h-index is a way to
Answer
Measure an author's productivity and impact
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,NIH Principles and Practices of Clinical Research (IPPCR) Final Exam.pdf file:///C:/Users/HP/Desktop/New%20folder/NIH%20Principles%20a
11. Clinical trial registration is important so that
Answer
A and B only
a) existing trials are publicly available; b) Trials are made publicly available even if they are not
finished
12. It is important to be able to replicate the randomization results, i.e., repro- duce the
string of treatment assignments.
Answer False
13. Scientific misconduct includes all of the following EXCEPT
Answer
human error
14. Which of the following four statements is TRUE about patents?
Answer To get worldwide patent protection, you will have to file a patent application in each
and every country.
15. Which of the following is NOT an example of a source document?
Answer A worksheet that has a patient's height and weight abstracted or taken from data in
the medical record.
16. True or False Planned interim data analyses, that require analysis of unblinded
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NIH Principles and Practices of Clinical Research
(IPPCR) Final Exam
1. Imhotep
Answer Egyptian, first physician figure to rise out of antiquity; known scribe, priest, architect,
astronomer and magician. performed surgery, practiced some dentistry, extracted medicine
from plants and knew the position and function of vital organs.
2. Hippocrates
Answer Father of modern medicine; Hipprocratic oath --> high moral stan- dards.
3. Which of the following is most likely a case series study?
Answer Report of 5 cases of pneumocytosis pneumonia in previously healthy homosexual men
4. Scientific misconduct can cause which of the following?
Answer All of the above
5. What is/are the reason(s) that NIH requires the inclusion of women and
minorities in all clinical research?
Answer All of the above
1/
1 of 16 9/5/2024, 2:57
,NIH Principles and Practices of Clinical Research (IPPCR) Final Exam.pdf file:///C:/Users/HP/Desktop/New%20folder/NIH%20Principles%20a
6. What can change a study's power and how power is impacted?
Answer Variation in outcome (Ã2 )p
ower decreases as an outcome's variance increases
7. A for-cause audit conducted by the Food and Drug Administration is best described as
Answer
An audit performed to investigate possible fraud or misconduct
8. The use of common data elements (CDEs) should meet all of the following objectives
EXCEPT
Answer
To promote unneeded or redundant data collection
9. True or False
Answer Tests of general cognitive function, such as IQ tests and mini-mental status
exams (MMSE), provide effective tools for determining whether individuals can give
informed consent for a clinical trial.
Answer False
10. An h-index is a way to
Answer
Measure an author's productivity and impact
2/
2 of 16 9/5/2024, 2:57
,NIH Principles and Practices of Clinical Research (IPPCR) Final Exam.pdf file:///C:/Users/HP/Desktop/New%20folder/NIH%20Principles%20a
11. Clinical trial registration is important so that
Answer
A and B only
a) existing trials are publicly available; b) Trials are made publicly available even if they are not
finished
12. It is important to be able to replicate the randomization results, i.e., repro- duce the
string of treatment assignments.
Answer False
13. Scientific misconduct includes all of the following EXCEPT
Answer
human error
14. Which of the following four statements is TRUE about patents?
Answer To get worldwide patent protection, you will have to file a patent application in each
and every country.
15. Which of the following is NOT an example of a source document?
Answer A worksheet that has a patient's height and weight abstracted or taken from data in
the medical record.
16. True or False Planned interim data analyses, that require analysis of unblinded
3/
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