2022
Moleculaire celbiologie
3DE BACHELOR BIO-INGENIEUR
KU LEUVEN - KIRSTEN VAN GILS
Kirsten Van Gils (2022)
,DEEL II: DE FLOW VAN GENETISCHE INFORMATIE
H7: REPLICATIE, ONDERHOUD EN HERSCHIKKING VAN GENOMISCH DNA
7.1. DNA REPLICATIE
7.1.1. DNA polymerase
7.1.2. De replicatie vork
7.1.3. the fidelity of replication
7.1.4. origins and the initiation of replication
7.1.5. telomeres and telomerase: maintaining the ends of chromosomes
VRAGEN H7
H8: RNA SYNTHESIS AND PROCESSING
8.2. EUKARYOTIC RNA POLYMERASES AND GENERAL TRANSCRIPTION FACTORS
8.2.1. Eukaryotic RNA polymerases
8.2.2. General transcription factors and initation of transcription by RNA polymerase II
8.2.3. transcription by RNA polymerases I and III
H9: TRANSCRIPTIONAL REGULATION AND EPIGENETICS
9.2. TRANSCRIPTION FACTORS IN EUKARYOTES
9.2.1. cis-acting regulatory sequences: promoters and enhancers
9.2.2. transcription factor binding sites
9.2.3. transcriptional regulatory proteins
9.2.4. structure and function of transcriptional activators
9.2.5. regulation of elongation
9.3. CHROMATIN AND EPIGENETICS
9.3.1. Relationship of chromatin structure to transcription
9.3.2. Histone modifications
9.3.3. Chromatin remodeling factors
9.3.4. Histones and epigenetic inheritance
9.3.5. DNA methylation
9.3.6. Noncoding RNAs
Kirsten Van Gils (2022)
,H8: RNA SYNTHESIS AND PROCESSING
8.3. RNA PROCESSING AND TURNOVER
8.3.1. Processing of mRNA in Eukaryotes
8.3.2. Splicing mechanisms
8.3.3. Alternative splicing
8.3.4. RNA editing
8.3.5. RNA degradation
VRAGEN H8-H9
DEEL III: CELSTRUCTUUR EN FUNCTIE
H11: THE NUCLEUS
11.1. THE NUCLEAR ENVELOPE AND TRAFFIC BETWEEN THE NUCLEUS AND THE CYTOPLASM
11.1.1. Structure of the nuclear envelope
11.1.2. Nuclear lamina diseases
11.1.3. The nuclear pore complex
11.1.4. Selective transport of proteins to and from the nucleus
11.1.5. Transport of RNAs
11.1.6. Regulation of nuclear protein import
11.2. THE ORGANIZATION OF CHROMATIN
11.2.1. Internal organization of the nucleus
11.2.2. Chromosome territories
11.2.3. Chromatin localization and transcriptional activity
11.2.4. Replication and transcription factories
11.3. NUCLEAR BODIES
11.3.1. The nucleolus and rRNA
11.3.2. Polycomb bodies: centers of transcriptional repression
11.3.3. Cajal bodies and speckles: processing and storage of snRNPs
VRAGEN H11
Kirsten Van Gils (2022)
,H12: PROTEIN SORTING AND TRANSPORT
12.1. THE ENDOPLASMIC RETICULUM
12.1.1. The endoplasmic reticulum and protein secretion
12.1.2. Targeting proteins to the endoplasmic reticulum
12.1.3. Insertion of proteins into the ER membrane
12.1.4. Protein folding and processing in the ER
12.1.5. Quality control in the ER
12.1.6. The smooth ER and lipid synthesis
12.1.7. Export of proteins and lipids from the ER
12.2. THE GOLGI APPARATUS
12.2.1. Organization of the golgi
12.2.2. Protein glycosylation within the Golgi
12.2.3. Lipid and polysaccharide metabolism in the Golgi
12.2.4. Protein sorting and export from the Golgi apparatus
12.3. THE MECHANISM OF VESICULAR TRANSPORT
12.3.1. Cargo selection, coat proteins, and vesicle budding
12.3.2. Vesicle fusion
12.4. LYSOSOMES
12.4.1. Lysosomal acid hydrolases
12.4.2. Endocytosis and lysosome formation
12.4.3. Phagocytosis and autophagy
VRAGEN H12
Kirsten Van Gils (2022)
,H13: ENERGY AND METABOLISME
13.1. MITOCHONDRIA
13.1.1. Organization and function of mitochondria
13.1.2. The genetic system of mitochondria
13.1.3. Mitochondrial replacement therapy
13.1.4. Protein import and mitochondrial assembly
13.1.5. Mitochondrial lipids
13.1.6. Transport of metabolits across the inner membrane
13.2. CHLOROPLASTS AND OTHER PLASTIDS
13.2.1. The structure and function of chloroplasts
13.2.2. The chloroplast genome
13.2.3. Import and sorting of chloroplast proteins
13.2.4. Other plastids
13.3. PEROXISOMES
13.3.1. Functions of peroxisomes
13.3.2. Peroxisome assembly
VRAGEN H13
Kirsten Van Gils (2022)
, H14: THE CYTOSKELETON AND CELL MOVEMENT
14.1. STRUCTURE AND ORGANIZATION OF ACTIN FILAMENTS
14.1.1. Assembly and organization of actin filaments
14.1.2. Association of actin filaments with the plasma membrane
14.1.3. Microvilli
14.1.4. Cell surface protrusions and cell movement
14.2. MYOSIN MOTORS
14.2.1. Muscle contraction
14.2.2. Contractile assemblies of actin and myosin in non-muscle cells
14.2.3. Unconventional myosin
14.3. MICROTUBULES
14.3.1. Structure and dynamic organization of microtubules
14.3.2. Assembly of microtubules
14.3.3. MAPs and the organization of microtubules
14.4. MICROTUBULE MOTORS AND MOVEMENT
14.4.1. Microtubule motor proteins
14.4.2. Cargo transport and intracellular organization
14.4.3. Cilia and flagella
14.4.4. Microtubules during mitosis
14.5. INTERMEDIATE FILAMENTS
14.5.1. Intermediate filament proteins
14.5.2. Assembly of intermediate filaments
14.5.3. Intracellular organization of intermediate filaments
VRAGEN H14
Kirsten Van Gils (2022)
Moleculaire celbiologie
3DE BACHELOR BIO-INGENIEUR
KU LEUVEN - KIRSTEN VAN GILS
Kirsten Van Gils (2022)
,DEEL II: DE FLOW VAN GENETISCHE INFORMATIE
H7: REPLICATIE, ONDERHOUD EN HERSCHIKKING VAN GENOMISCH DNA
7.1. DNA REPLICATIE
7.1.1. DNA polymerase
7.1.2. De replicatie vork
7.1.3. the fidelity of replication
7.1.4. origins and the initiation of replication
7.1.5. telomeres and telomerase: maintaining the ends of chromosomes
VRAGEN H7
H8: RNA SYNTHESIS AND PROCESSING
8.2. EUKARYOTIC RNA POLYMERASES AND GENERAL TRANSCRIPTION FACTORS
8.2.1. Eukaryotic RNA polymerases
8.2.2. General transcription factors and initation of transcription by RNA polymerase II
8.2.3. transcription by RNA polymerases I and III
H9: TRANSCRIPTIONAL REGULATION AND EPIGENETICS
9.2. TRANSCRIPTION FACTORS IN EUKARYOTES
9.2.1. cis-acting regulatory sequences: promoters and enhancers
9.2.2. transcription factor binding sites
9.2.3. transcriptional regulatory proteins
9.2.4. structure and function of transcriptional activators
9.2.5. regulation of elongation
9.3. CHROMATIN AND EPIGENETICS
9.3.1. Relationship of chromatin structure to transcription
9.3.2. Histone modifications
9.3.3. Chromatin remodeling factors
9.3.4. Histones and epigenetic inheritance
9.3.5. DNA methylation
9.3.6. Noncoding RNAs
Kirsten Van Gils (2022)
,H8: RNA SYNTHESIS AND PROCESSING
8.3. RNA PROCESSING AND TURNOVER
8.3.1. Processing of mRNA in Eukaryotes
8.3.2. Splicing mechanisms
8.3.3. Alternative splicing
8.3.4. RNA editing
8.3.5. RNA degradation
VRAGEN H8-H9
DEEL III: CELSTRUCTUUR EN FUNCTIE
H11: THE NUCLEUS
11.1. THE NUCLEAR ENVELOPE AND TRAFFIC BETWEEN THE NUCLEUS AND THE CYTOPLASM
11.1.1. Structure of the nuclear envelope
11.1.2. Nuclear lamina diseases
11.1.3. The nuclear pore complex
11.1.4. Selective transport of proteins to and from the nucleus
11.1.5. Transport of RNAs
11.1.6. Regulation of nuclear protein import
11.2. THE ORGANIZATION OF CHROMATIN
11.2.1. Internal organization of the nucleus
11.2.2. Chromosome territories
11.2.3. Chromatin localization and transcriptional activity
11.2.4. Replication and transcription factories
11.3. NUCLEAR BODIES
11.3.1. The nucleolus and rRNA
11.3.2. Polycomb bodies: centers of transcriptional repression
11.3.3. Cajal bodies and speckles: processing and storage of snRNPs
VRAGEN H11
Kirsten Van Gils (2022)
,H12: PROTEIN SORTING AND TRANSPORT
12.1. THE ENDOPLASMIC RETICULUM
12.1.1. The endoplasmic reticulum and protein secretion
12.1.2. Targeting proteins to the endoplasmic reticulum
12.1.3. Insertion of proteins into the ER membrane
12.1.4. Protein folding and processing in the ER
12.1.5. Quality control in the ER
12.1.6. The smooth ER and lipid synthesis
12.1.7. Export of proteins and lipids from the ER
12.2. THE GOLGI APPARATUS
12.2.1. Organization of the golgi
12.2.2. Protein glycosylation within the Golgi
12.2.3. Lipid and polysaccharide metabolism in the Golgi
12.2.4. Protein sorting and export from the Golgi apparatus
12.3. THE MECHANISM OF VESICULAR TRANSPORT
12.3.1. Cargo selection, coat proteins, and vesicle budding
12.3.2. Vesicle fusion
12.4. LYSOSOMES
12.4.1. Lysosomal acid hydrolases
12.4.2. Endocytosis and lysosome formation
12.4.3. Phagocytosis and autophagy
VRAGEN H12
Kirsten Van Gils (2022)
,H13: ENERGY AND METABOLISME
13.1. MITOCHONDRIA
13.1.1. Organization and function of mitochondria
13.1.2. The genetic system of mitochondria
13.1.3. Mitochondrial replacement therapy
13.1.4. Protein import and mitochondrial assembly
13.1.5. Mitochondrial lipids
13.1.6. Transport of metabolits across the inner membrane
13.2. CHLOROPLASTS AND OTHER PLASTIDS
13.2.1. The structure and function of chloroplasts
13.2.2. The chloroplast genome
13.2.3. Import and sorting of chloroplast proteins
13.2.4. Other plastids
13.3. PEROXISOMES
13.3.1. Functions of peroxisomes
13.3.2. Peroxisome assembly
VRAGEN H13
Kirsten Van Gils (2022)
, H14: THE CYTOSKELETON AND CELL MOVEMENT
14.1. STRUCTURE AND ORGANIZATION OF ACTIN FILAMENTS
14.1.1. Assembly and organization of actin filaments
14.1.2. Association of actin filaments with the plasma membrane
14.1.3. Microvilli
14.1.4. Cell surface protrusions and cell movement
14.2. MYOSIN MOTORS
14.2.1. Muscle contraction
14.2.2. Contractile assemblies of actin and myosin in non-muscle cells
14.2.3. Unconventional myosin
14.3. MICROTUBULES
14.3.1. Structure and dynamic organization of microtubules
14.3.2. Assembly of microtubules
14.3.3. MAPs and the organization of microtubules
14.4. MICROTUBULE MOTORS AND MOVEMENT
14.4.1. Microtubule motor proteins
14.4.2. Cargo transport and intracellular organization
14.4.3. Cilia and flagella
14.4.4. Microtubules during mitosis
14.5. INTERMEDIATE FILAMENTS
14.5.1. Intermediate filament proteins
14.5.2. Assembly of intermediate filaments
14.5.3. Intracellular organization of intermediate filaments
VRAGEN H14
Kirsten Van Gils (2022)
