COAGULATION AAB MT EXAM
QUESTIONS WITH COMPLETE
ANSWERS
What factor is not a serine protease- it is a fibrin stabilizing transglutaminase that forms
cross bridges in the fibrin clot. It is a calcium-dependent enzyme activated by thrombin?
- Answer-Factor XIIIa
What is the tissue factor pathway? - Answer-Extrinsic pathway
What can activate factor VII in plasma when exposed to glass or other surfaces -
Answer-Factor IX and kallikrein
What does the prothrombinase complex include? - Answer-Xa-Va-Ca2+-PL
What is the most important physiological inhibitor of plasmin? - Answer-alpha2
antiplasmin
Principal inhibitor of thrombin and factor Xa - Answer-Antithrombin III
What is the most frequent of acquired inhibitors, associated with increased risk of
thrombosis, and directed at phospholipid or phospholipoprotein components involved in
activation of coagulation factors? - Answer-Lupus-like coagulant
What diagnostic test is used for fibrinogen inhibitors? - Answer-TT
Treatment with what pharmacological agent increases both factor VIII and VWF i mild to
moderate cases? - Answer-DDAVP
Disseminated intravascular coagulopathy - Answer-Serious disorder in which the
proteins that control blood clotting become over active
Most common abnormality associated with bleeding - Answer-Thrombocytopenia
Thrombocytopenia - Answer-Any disorder in which there is an abnormally low amount of
platelets.
Factors VII, X, V, II, I - Answer-Necessary for normal prothrombin time
Only test to measure factor VII - Answer-PT
Test to evaluate intrinsic system of coagulation - Answer-Activated partial
thromboplastin time (APTT)
QUESTIONS WITH COMPLETE
ANSWERS
What factor is not a serine protease- it is a fibrin stabilizing transglutaminase that forms
cross bridges in the fibrin clot. It is a calcium-dependent enzyme activated by thrombin?
- Answer-Factor XIIIa
What is the tissue factor pathway? - Answer-Extrinsic pathway
What can activate factor VII in plasma when exposed to glass or other surfaces -
Answer-Factor IX and kallikrein
What does the prothrombinase complex include? - Answer-Xa-Va-Ca2+-PL
What is the most important physiological inhibitor of plasmin? - Answer-alpha2
antiplasmin
Principal inhibitor of thrombin and factor Xa - Answer-Antithrombin III
What is the most frequent of acquired inhibitors, associated with increased risk of
thrombosis, and directed at phospholipid or phospholipoprotein components involved in
activation of coagulation factors? - Answer-Lupus-like coagulant
What diagnostic test is used for fibrinogen inhibitors? - Answer-TT
Treatment with what pharmacological agent increases both factor VIII and VWF i mild to
moderate cases? - Answer-DDAVP
Disseminated intravascular coagulopathy - Answer-Serious disorder in which the
proteins that control blood clotting become over active
Most common abnormality associated with bleeding - Answer-Thrombocytopenia
Thrombocytopenia - Answer-Any disorder in which there is an abnormally low amount of
platelets.
Factors VII, X, V, II, I - Answer-Necessary for normal prothrombin time
Only test to measure factor VII - Answer-PT
Test to evaluate intrinsic system of coagulation - Answer-Activated partial
thromboplastin time (APTT)
