PTxIII Cancer Exam 4 | 100% Correct Answers | Verified | Latest 2024 Version

What are the 3 phases of chronic myelogenous leukemia (CML)? - 1. Chronic (increase in WBCs or Plts and splenomegaly, "stable phase" lasting 1-4 years) 2. Accelerated phase ( ~ few months) 3. Blast phase (transition to ACUTE leukemia) What is the ONLY CURE for CML? - Allogeneic HSCT (stem cell transplant) When is AHSCT indicated? - Blast crisis accelerated phase unresponsive or intolerant to TKIs What is the purpose of TKIs in treating CML? - To maintain patient in the chronic phase "stable phase" Which 5 TKIs are approved for CML? Hint: I DONT NEED BLOOD PUNK - Imatinib Dasatinib Nilotinib Bosutinib Ponatinib Imatinib (Gleevec) AEs - Neutropenia, thrombocytopenia, edema, rash, CHF, cardiotoxicity (T/F) imatinib is taken without regard to meals - False, imatinib should be taken WITH FOOD!!Which CYP enzymes does imatinib inhibit and which drug is contraindicated to be taken with imatinib? - Imatinib inhibits CYP2C9 and CYP2D6