GI Pharmacology Exam Elaboration with 100% Correct Answers

GI Pharmacology Exam Elaboration with 100% Correct Answers H2 Blockers *Ans* Cimetidine, ranitidine, famotidine, nizatidine H2 Blockers: Mechanism; (Reversible or Irreversible?) block of histamine H2 receptors ---> ? *Ans* Reversible block of histamine H2 receptors ---> Decreased H+ secretion by parietal cells. H2 Blockers: Clinical Use *Ans* Peptic ulcer, gastritis, mild esophageal reflux What are the toxic effects of Cimetidine? *Ans* Potent inhibitor of P-450; Antiandrogenic effects; Can cross blood-brain barrier and placenta. What H2 Blockers cause decreased renal excretion of creatinine? *Ans* Cimetidine and Ranitidine List the main PPIs *Ans* Omeprazole, lansoprazole PPIs: Mechanism *Ans* Irreversibly inhibit H+/K+-ATPase in stomach parietal cells PPIs: Clinical Use *Ans* Peptic ulcer, gastritis, esophageal reflux, Zollinger-Ellison syndrome Sucralfate: Mechanism *Ans* Bind to ulcer base, provide physical protection, allow HCO3- secretion to reestablish pH gradient in mucous layer. What drug(s) have the following mechanism? Bind to ulcer base, provide physical protection, allow HCO3- secretion to reestablish pH gradient in mucous layer. *Ans* Sucralfate, Bismuth Sucralfate, Bismuth: clinical use *Ans* Increases ulcer healing; traveler's diarrhea What drug(s) have the following mechanism? Irreversibly inhibit H+/K+-ATPase in stomach parietal cells *Ans* PPIs: Omeprazole, lansoprazole What drug(s) have the following clinical uses? Peptic ulcer, gastritis, esophageal reflux, Zollinger-Ellison syndrome *Ans* PPIs: Omeprazole, lansoprazole What drug(s) have the following clinical uses? Increases ulcer healing; traveler's diarrhea *Ans* Sucralfate, Bismuth