Discovery Lab Exam 3 Questions with Complete Solutions

IACUC - ANSWER-reviews proposed animal experiments. All experiments involving vertebrate animals are subject to approval by the IACUC prior to beginning experiments. The proposed experiments must be submitted to and approved by the IACUC in the form of a document called a protocol. Each animal protocol must include: - ANSWER-1. a justification for using animals, the number of animals being used, and the species chosen 2. the procedures or drugs to be used to eliminate or minimize pain and discomfort along with justification of the choice 3. a description of the methods and sources used to search for alternatives to painful procedures 4. a description of the search used to ensure that the experiment does not unnecessarily duplicate previous research The committee of the IACUC must include: - ANSWER-Doctor of Veterinary Medicine, one scientist experienced in animal research, a professional whose primary concerns are not scientific, and a member who is not affiliated with the institution in any way and who is meant to represent the interests of the community at large. IRB - ANSWER-reviews protocols involving experiments with humans. Can also include interviews and focus groups, surveys, and medical charts. Belmont Report - ANSWER-a report on basic research ethic guidelines that outlines three basic principles: respect for persons, beneficence, and justice. 3 R's - ANSWER-replacement of conscious living animals with non-sentient animals or materials, reduction of the number of animals used in an experiment or procedure, and refinement of the techniques used in order to decrease the incidence or amount of animal pain and distress. fabrication - ANSWER-involves making up data or results, notes, or other research information and recording or reporting them. falsification - ANSWER-involves manipulation of research materials, equipment or processes, or changing or omitting data/results such that the research is not accurately represented in the research record. RIO - ANSWER-Research & Innovation office: protects the integrity of research. They also coordinate efforts to ensure ethical collaboration with pharmaceutical companies, to develop grant applications, to propose and complete work with animal and human subjects, and protect vulnerable trainees.