Hematology CSMLS exam questions and answers

Hematology CSMLS exam questions and answers Adult Hematopoiesis - CORRECT ANS-Skull, sternum, pelvis, ribs and vertebrae. Flat bones: active adult hemopoietic tissue (colony forming units in red marrow) Prenatal hematopoiesis - CORRECT ANS-Begins in the yolk sac, then fetal liver, and then bone marrow at birth Hemoglobin - CORRECT ANS-An iron-containing protein in red blood cells that reversibly binds oxygen. - Must have iron and protoporphyrin Transferrin - CORRECT ANS-iron transport protein Ferritin - CORRECT ANS-Major Fe Storage form Hemosiderin - CORRECT ANS-H2O insoluble Fe storage form (long term) Hemosiderosis - CORRECT ANS-abnormal increase of iron in blood, excess iron stored in tissues and body organs Early Heme Precursors - CORRECT ANS-Delta-aminolevulinic acid Porphobilinogen Late Heme Precursors - CORRECT ANS-Uroporphyrinogen - Coproporphyrinogen - Protoporphyrin - Heme Shift to Left Hgb-O2 Dissociation - CORRECT ANS-O2 not released to tissue adequately - Decreased CO2 - Increased pH - HbF (High affinity Hb) - Multiple transfusions (Decreased 2,3-DPG) Shift to Right Hgb-O2 Dissociation - CORRECT ANS-O2 released to tissue more easily - Increased CO2 - Decreased pH - Increased 2,3-DPG HbF - CORRECT ANS-Fetal hemoglobin A2Y2. 2 alpha, 2 gamma chains 60-90% in Newborns