Pharmacology: A Patient-Centered Nursing Process Approach 11th Edition legal and basic principles and answers

Pharmacokinetics - ans ====the process of drug movement throughout the body necessary to achieve drug action Absorption - ans ====the movement of the drug into the bloodstream after administration Bioavailability - ans ====percentage of administered drug available for activity First Pass Effect (Metabolism) - ans ====some drugs are metabolized to an inactive form and are excreted, thus reducing the amount of active drug available to exert a pharmacologic effect Distribution - ans ====movement of the drug from the circulation to body tissues Distribution is affected by - ans ====Blood flow to tissues Faster: heart , liver, kidneys, and brain Slower: muscle, skin, and fat blood-brain barrier - ans ====limits and slows effect lipid soluble meds can pass Protein binding of drugs - ans ====binds with most protein (albumin) Drug-Drug interactions - ans ====2 meds are trying to be bound one will not be as bound as the other so it will have less effect and there is a risk of toxicity Metabolism - ans ====the process by which the body chemically changes drugs into a form that can be excreted P-450 enzyme - ans ====helps break down the med and evacuate