CPPS 325 FINAL EXAM QUESTIONS WITH COMPLETE SOLUTIONS

CPPS 325 FINAL EXAM QUESTIONS WITH COMPLETE SOLUTIONS RTK vs. Serine/Threonine Phosphorylation ? - Answer-Tyrosine phosphorylation is rare (1%) relative to serine/threonine residue phosphorylation. Tyrosine phosphorylation is the major mechanism of receptor signal transduction. What is the net effect of activated TKs? - Answer-Tyrosine phosphorylation on target proteins. What do TK pathways mediate? - Answer-Cell growth (growth factors), differentiation, host defense, metabolic regulation, cell survival pathways (survival factors). What are amplifiers of the TK pathways? - Answer-PI3-K -> PIP3 PLC -> DAG and InsP3&Ca2+ What are RTK mediated actions in the cell? - Answer-regulation of cell proliferation, differentiation, and cell motility, promotion of cell survival and modulation of cellular metabolism. TKs exist in either the cytosol or as transmembrane receptors, what are the differences in the two types? - Answer-Cytosol receptors have an src N-terminal region. Cytosol has no membrane spanning domain. TM receptor has a single membrane spanning hydrophobic TM domain. Ex) Epidermal GF RTK.