Samenvatting prof. Van wijngaerden (alle leerstof inhoudstabel)

I NH OU D

Pathofysiologie...........................................................................................................................................................................................................................................................10

Microbiële virulente..............................................................................................................................................................................................................................................10

Primair pathogene micro-organismen...............................................................................................................................................................................................................11

Potenteel pathogene micro-organismen..........................................................................................................................................................................................................11

Opportunistsch pathogene micro-organismen.................................................................................................................................................................................................11

Pathogenese..............................................................................................................................................................................................................................................................11

Afweermechanismen.............................................................................................................................................................................................................................................12

Huid- en mucosa-barrière..................................................................................................................................................................................................................................12

Humorale afweermechanismen........................................................................................................................................................................................................................12

Cellulaire afweermechanismen.........................................................................................................................................................................................................................13

Epidemiologie............................................................................................................................................................................................................................................................13

Defenites...............................................................................................................................................................................................................................................................14

Reservoir................................................................................................................................................................................................................................................................14

Transmissie/overdracht.........................................................................................................................................................................................................................................14

Diagnose.................................................................................................................................................................................................................................................................14

Microbiologische diagnostee....................................................................................................................................................................................................................................14

Defenites...................................................................................................................................................................................................................................................................15

Etologie.....................................................................................................................................................................................................................................................................15

In/buiten zieeenhuis..............................................................................................................................................................................................................................................15

Geeende of ongeeende ingangspoort...................................................................................................................................................................................................................16

Prognose....................................................................................................................................................................................................................................................................16


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, Piro.........................................................................................................................................................................................................................................................................16

Andere....................................................................................................................................................................................................................................................................16

Mortaliteit..............................................................................................................................................................................................................................................................16

Pathogenese..............................................................................................................................................................................................................................................................16

Infammatoire respons...........................................................................................................................................................................................................................................16

Effect..................................................................................................................................................................................................................................................................17

Doel....................................................................................................................................................................................................................................................................17

Ant infammatoire respons...................................................................................................................................................................................................................................17

Prognose....................................................................................................................................................................................................................................................................19

PIRO........................................................................................................................................................................................................................................................................19

Andere....................................................................................................................................................................................................................................................................19

Behandeling...............................................................................................................................................................................................................................................................19

Ant-infecteus beleid.............................................................................................................................................................................................................................................19

Supporteve (intensieve) zorgen............................................................................................................................................................................................................................19

Ant-infammatoire modulate...............................................................................................................................................................................................................................19

Bijzondere gevallen van sepsis..................................................................................................................................................................................................................................19

Sepsis zonder sprecefeee orgaanloealisate.........................................................................................................................................................................................................19

Zieete van Lyme: lyme borreliose..............................................................................................................................................................................................................................20

Symptomen............................................................................................................................................................................................................................................................20

Vroeg geloeealiseerde infecte: dagen tot weeen.............................................................................................................................................................................................21

vroege gedissemineerde infecte: weeen tot maanden....................................................................................................................................................................................21

Stadium 3 (late) : maanden tot jaren.................................................................................................................................................................................................................21

Prevente................................................................................................................................................................................................................................................................21

2

, Diagnose.................................................................................................................................................................................................................................................................21

Behandeling...........................................................................................................................................................................................................................................................21

Oorzaeen van therapiefalen..............................................................................................................................................................................................................................21

Syflis..........................................................................................................................................................................................................................................................................22

Kliniee.....................................................................................................................................................................................................................................................................22

Primair stadium..................................................................................................................................................................................................................................................22

Secundair stadium:............................................................................................................................................................................................................................................22

Latent stadium...................................................................................................................................................................................................................................................22

Tertaire stadium................................................................................................................................................................................................................................................22

Diagnose.................................................................................................................................................................................................................................................................23

Behandeling...........................................................................................................................................................................................................................................................23

Kattenerabzieete........................................................................................................................................................................................................................................................23

Kliniee.....................................................................................................................................................................................................................................................................23

Atypisch..............................................................................................................................................................................................................................................................23

Diagnose.................................................................................................................................................................................................................................................................23

behandeling...........................................................................................................................................................................................................................................................24

Brucellose...................................................................................................................................................................................................................................................................24

Besmetngsbronnen..............................................................................................................................................................................................................................................24

Symptomen............................................................................................................................................................................................................................................................25

DIagnose................................................................................................................................................................................................................................................................25

Behandeling...........................................................................................................................................................................................................................................................25

Infecteuze endocardits.............................................................................................................................................................................................................................................25

Voorbechiete factoren...........................................................................................................................................................................................................................................25

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, Oorzaeelijee organismen.......................................................................................................................................................................................................................................25

Vegetate................................................................................................................................................................................................................................................................26

Gevolgen............................................................................................................................................................................................................................................................26

Typische letsels..................................................................................................................................................................................................................................................26

Diagnose.................................................................................................................................................................................................................................................................26

Behandeling...........................................................................................................................................................................................................................................................27

Prevente................................................................................................................................................................................................................................................................27

Acute bacteriële meningits.......................................................................................................................................................................................................................................27

Risicofactoren........................................................................................................................................................................................................................................................27

Symptomen en teeens...........................................................................................................................................................................................................................................27

Verwieeelingen...................................................................................................................................................................................................................................................28

Diagnose.................................................................................................................................................................................................................................................................28

Behandeling..........................................................................................................................................................................................................................................................28

Prevente................................................................................................................................................................................................................................................................28

Vaccinate bij einderen.......................................................................................................................................................................................................................................28

Vaccinate bij reizigers/pelgrims Meeea............................................................................................................................................................................................................29

Malaria.......................................................................................................................................................................................................................................................................29

Epidemiologie........................................................................................................................................................................................................................................................29

Cyclus.................................................................................................................................................................................................................................................................29

Stabiel vs onstabiel............................................................................................................................................................................................................................................30

Immuniteit.............................................................................................................................................................................................................................................................30

Symptomen............................................................................................................................................................................................................................................................31

Verwieeelingen...................................................................................................................................................................................................................................................31

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, Diagnose.................................................................................................................................................................................................................................................................31

Behandeling...........................................................................................................................................................................................................................................................32

Geneesmiddelen................................................................................................................................................................................................................................................32

pREVENTIE..............................................................................................................................................................................................................................................................33

pREVETIE LOKALE BEVOLKING...........................................................................................................................................................................................................................33

Prevente bij reizigers.........................................................................................................................................................................................................................................33

Toxoplasmose............................................................................................................................................................................................................................................................33

Symptomen............................................................................................................................................................................................................................................................34

Congenitale toxoplasmose.................................................................................................................................................................................................................................34

Verworven toxoplasmose..................................................................................................................................................................................................................................34

Orgaanloealisates..............................................................................................................................................................................................................................................34

Diagnose.................................................................................................................................................................................................................................................................34

Behandeling...........................................................................................................................................................................................................................................................34

Schistosomiase...........................................................................................................................................................................................................................................................34

Cyclus.....................................................................................................................................................................................................................................................................35

Pathogenese en symptomen: 3 syndromen..........................................................................................................................................................................................................35

dermatts (cercariae) .........................................................................................................................................................................................................................................35

Katayama-eoorts (volwassen worm) .................................................................................................................................................................................................................36

Chronische fbro-obstructeve seewellen (eieren) .............................................................................................................................................................................................36

Diagnose.................................................................................................................................................................................................................................................................36

Behandeling...........................................................................................................................................................................................................................................................36

Prevente................................................................................................................................................................................................................................................................36

ECHOCOCCOSE...........................................................................................................................................................................................................................................................36

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, Pathogenese en symptomen.................................................................................................................................................................................................................................37

Diagnose.................................................................................................................................................................................................................................................................37

Behandeling...........................................................................................................................................................................................................................................................37

Strongyloidiasis..........................................................................................................................................................................................................................................................37

Pathogenese en symptomen.................................................................................................................................................................................................................................38

Hyperinfecte syndroom....................................................................................................................................................................................................................................38

dIAGNOSE...............................................................................................................................................................................................................................................................38

Behandeling...........................................................................................................................................................................................................................................................39

Filariase......................................................................................................................................................................................................................................................................39

Lymfatsche flariase..............................................................................................................................................................................................................................................39

pathogenese en Cyclus......................................................................................................................................................................................................................................39

Symptomen........................................................................................................................................................................................................................................................39

Diagnose.............................................................................................................................................................................................................................................................39

Behandeling.......................................................................................................................................................................................................................................................40

LOA LOA.................................................................................................................................................................................................................................................................40

Pathogenese en cyclus.......................................................................................................................................................................................................................................40

Symptomen........................................................................................................................................................................................................................................................40

Diagnose.............................................................................................................................................................................................................................................................40

Behandeling.......................................................................................................................................................................................................................................................40

Onchocerca volvulus..............................................................................................................................................................................................................................................40

Pathogenese en cyclus.......................................................................................................................................................................................................................................41

Klinische symptomen.........................................................................................................................................................................................................................................41

Diagnose.............................................................................................................................................................................................................................................................41

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, Behandeling.......................................................................................................................................................................................................................................................41

Infuenzavirus: griep...................................................................................................................................................................................................................................................41

sYMPTOMEN EN VERWIKKELINGEN..................................................................................................................................................................................................................42

Diagnose.............................................................................................................................................................................................................................................................42

Behandeling.......................................................................................................................................................................................................................................................42

Prevente............................................................................................................................................................................................................................................................42

Pandemische infuenza..........................................................................................................................................................................................................................................42

Gevolgen............................................................................................................................................................................................................................................................42

Pandemisch fasen who......................................................................................................................................................................................................................................43

Surveillance........................................................................................................................................................................................................................................................43

Avian infuenza.......................................................................................................................................................................................................................................................43

Infuenza A/ H5N1..............................................................................................................................................................................................................................................43

Infenza A/H7N9.................................................................................................................................................................................................................................................43

Seizoensgriep.........................................................................................................................................................................................................................................................43

Transmissie........................................................................................................................................................................................................................................................43

Herpes........................................................................................................................................................................................................................................................................44

Epstein Barr virus...................................................................................................................................................................................................................................................44

Transmissie........................................................................................................................................................................................................................................................44

Symptomen........................................................................................................................................................................................................................................................44

Diagnose en behandelingen..............................................................................................................................................................................................................................44

Cytomegalovirus....................................................................................................................................................................................................................................................44

Symptomen........................................................................................................................................................................................................................................................45

Behandeling en prevente..................................................................................................................................................................................................................................45

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, Herpes simplex.......................................................................................................................................................................................................................................................45

Symptomen en transmissie...............................................................................................................................................................................................................................45

dIAGNOSE EN bEHANDELING.............................................................................................................................................................................................................................46

Varicella zoster.......................................................................................................................................................................................................................................................46

Symptomen, verwieeelingen, diagnose en behandelingen...............................................................................................................................................................................46

Hantavirus..................................................................................................................................................................................................................................................................46

Puumulavirus (noord-west- europa) .................................................................................................................................................................................................................47

HIV en AIDS................................................................................................................................................................................................................................................................47

HIV1....................................................................................................................................................................................................................................................................47

Gevolgen HIV..........................................................................................................................................................................................................................................................48

Diagnose.................................................................................................................................................................................................................................................................48

Behandeling...........................................................................................................................................................................................................................................................48

Antretrovirale therapie.....................................................................................................................................................................................................................................48

Combinatetherapie (combinaton antretroviral therapy cart) ........................................................................................................................................................................49

Profylaxie...........................................................................................................................................................................................................................................................49

Van dodelije naar chronische zieete......................................................................................................................................................................................................................49

Sarcoïdose..................................................................................................................................................................................................................................................................49

Etologie.................................................................................................................................................................................................................................................................49

Pathogenese..........................................................................................................................................................................................................................................................49

Kliniee.....................................................................................................................................................................................................................................................................50

Diagnose.................................................................................................................................................................................................................................................................50

Behandeling...........................................................................................................................................................................................................................................................50

Tuberculose................................................................................................................................................................................................................................................................51

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