NR 565 Midterm Study Guide
latest 2024
NR565 Week 4 Study Guide Week 4 is the midterm (no quiz) and includes all material from
Weeks 1-4; Be sure to also review the Weeks 1, 2 & 3 study guides to prepare for the exam
Many questions will are written to assess your clinical application of the material from the
textbook, in real-world scenarios
Chapter 15: Drugs Affecting the Central Nervous System
Anorexiants: phentermine/Adipex, benzphetamine/Didrex, diethylpropion HCL/Tenuate,
phendimetrazine/Bontril, lorcaserin/Belviq. Precautions and contraindications-use with
caution in diabetics and individuals with substance abuse, do not prescribe with MAOs (HTN
crisis), or serotonin (serotonin syndrome)
Anticonvulsants: phenobarbital, Depakote, gabapentin, valproates, lamotrigine. (all can
increase S/S)
Hydantoins-phenytoin/Dilantin, ethotoin/Peganone, osohentoin/Cerebyx-1st line of defense
for clonic-tonic working on the motor cortex to slow abnormal charges. ADRs- phenytoin
induced HEP, cardiovascular reactions to fast IV push, contraindicated for brady, blocks,
strokes- (assess for fever, rash, lymphadenopathy) do not stop abruptly/monitor blood
levels
Iminostilbenes-carbamazepine/Tegretol, oxcarbazepine/Trileptal, treats epilepsy, bipolar,
aggressive disorders reducing abnormal activity-slows influx of sodium in cortical neurons-
, NR 565 Midterm Study Guide
latest 2024
contraindicated for bone marrow suppression, No grapefruit juice MAOs, Preg D, BBW-
Steven’s John Syndrome/toxic necrolysis in Chinese/blood dycrasias-monitor
blood levels/decrease effectiveness of oral contraceptives Succinimides-
ethosuximide/Zarontin, methsuximide/Celontin-treats absence seizure by decreasing nerve
impulses in the motor cortex-ADRs-GI upset take with food, avoid ETOH--(monitor blood
levels)
Drugs that affect GABA: benzodiazepines, gabapentin/Neurontin, topiramate/Topamax,
tiagabine/Gabitril- monitor S/I, weight, ability to sweat, bicarbonate levels, and seizure activity-
may cause false+ urine protein, somnolence, and dizziness
Antidepressants: TCAs, SSRIs, MAOIs, SNRIs, miscellaneous (S/I BBW all) All
Metabolized in the liver
Monoamine Oxidase Inhibitors (MAOIs): phenelzine/Nardil, isocarboxazid/Marplan,
tranylcypromine/Parnate, selegiline/Emsam- 1st generation, blocks metabolizing enzymes on
dopamine, norepinephrine, serotonin. Fast acting within 2 weeks.
Contraindication includes liver disease, CHF, SRI, SNRI. Avoid tyramine and all food and drugs
that could raise BP, no chocolate, caffeine, yogurt, sour cream, aged meat, and cheese. HTN
crisis symptoms include palpitations, stiff neck, headache, chest tightness, and tachycardia.
latest 2024
NR565 Week 4 Study Guide Week 4 is the midterm (no quiz) and includes all material from
Weeks 1-4; Be sure to also review the Weeks 1, 2 & 3 study guides to prepare for the exam
Many questions will are written to assess your clinical application of the material from the
textbook, in real-world scenarios
Chapter 15: Drugs Affecting the Central Nervous System
Anorexiants: phentermine/Adipex, benzphetamine/Didrex, diethylpropion HCL/Tenuate,
phendimetrazine/Bontril, lorcaserin/Belviq. Precautions and contraindications-use with
caution in diabetics and individuals with substance abuse, do not prescribe with MAOs (HTN
crisis), or serotonin (serotonin syndrome)
Anticonvulsants: phenobarbital, Depakote, gabapentin, valproates, lamotrigine. (all can
increase S/S)
Hydantoins-phenytoin/Dilantin, ethotoin/Peganone, osohentoin/Cerebyx-1st line of defense
for clonic-tonic working on the motor cortex to slow abnormal charges. ADRs- phenytoin
induced HEP, cardiovascular reactions to fast IV push, contraindicated for brady, blocks,
strokes- (assess for fever, rash, lymphadenopathy) do not stop abruptly/monitor blood
levels
Iminostilbenes-carbamazepine/Tegretol, oxcarbazepine/Trileptal, treats epilepsy, bipolar,
aggressive disorders reducing abnormal activity-slows influx of sodium in cortical neurons-
, NR 565 Midterm Study Guide
latest 2024
contraindicated for bone marrow suppression, No grapefruit juice MAOs, Preg D, BBW-
Steven’s John Syndrome/toxic necrolysis in Chinese/blood dycrasias-monitor
blood levels/decrease effectiveness of oral contraceptives Succinimides-
ethosuximide/Zarontin, methsuximide/Celontin-treats absence seizure by decreasing nerve
impulses in the motor cortex-ADRs-GI upset take with food, avoid ETOH--(monitor blood
levels)
Drugs that affect GABA: benzodiazepines, gabapentin/Neurontin, topiramate/Topamax,
tiagabine/Gabitril- monitor S/I, weight, ability to sweat, bicarbonate levels, and seizure activity-
may cause false+ urine protein, somnolence, and dizziness
Antidepressants: TCAs, SSRIs, MAOIs, SNRIs, miscellaneous (S/I BBW all) All
Metabolized in the liver
Monoamine Oxidase Inhibitors (MAOIs): phenelzine/Nardil, isocarboxazid/Marplan,
tranylcypromine/Parnate, selegiline/Emsam- 1st generation, blocks metabolizing enzymes on
dopamine, norepinephrine, serotonin. Fast acting within 2 weeks.
Contraindication includes liver disease, CHF, SRI, SNRI. Avoid tyramine and all food and drugs
that could raise BP, no chocolate, caffeine, yogurt, sour cream, aged meat, and cheese. HTN
crisis symptoms include palpitations, stiff neck, headache, chest tightness, and tachycardia.
