Maryville Nurs 660 Exam 2
SSRIs
selective serotonin reuptake inhibitors
Seriously Prepare Cities for the Flu Vaccine
-Sertaline (Zoloft)
--Paroxetine (Paxil)
-Citolpram(Celexa)
-Escitalopram (Lexapro)
-Fluoxetine HCl (Prozac)
--Fluvoxamine (Luvox)
-(Viibryd)Citol
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SSRI mechanism of action
Blocks the reuptake of serotonin (only serotonin) thus increasing it's effects
All inhibit the serotonin transporter SERT
SSRI side effects
Gastrointestinal disturbances
Sexual dysfunction
Drowsiness / insomnia
Serotonin Syndrome (rare)
SSRI discontinuation
, sx
uMost common side effects include GI upset, sexual dysfunction (30%+!), anxiety, restlessness,
nervousness, insomnia, fatigue or sedation, dizziness
uVery little risk of cardiotoxicity in overdose
uCan develop a discontinuation syndrome with agitation, nausea, disequilibrium and dysphoria
SSRIs treat
anxiety
depression
SSRI discontinuation syndrome
A drug withdrawal syndrome associated with the use of at least some of the SSRI and SNRI
antidepressants.
SSRI discontinuation syndrome symptoms
flu-like symptoms, dizziness, weakness, nausea, fatigue, feelings of "unreality," loss of balance,
light-headedness, "electric-shock" sensations, and other symptoms.
Paroxitine (Paxil) Pros
Short half life with no active metabolite means no build-up (which is good if hypomania
develops)
Sedating properties (dose at night) offers good initial relief from anxiety and insomnia
Paroxitine (Paxil) Cons
Significant CYP2D6 inhibition
Sedating, wt gain, more anticholinergic effects
sexual side effects
Notorious for discontinuation syndrome
Sertraline (Zoloft) Pros
Very weak P450 interactions (only slight CYP2D6)
Short half life with lower build-up of metabolites
Less sedating when compared to paroxetine
Sertraline (Zoloft) Cons
Max absorption requires a full stomach
Increased number of GI adverse drug reactions
SSRIs
selective serotonin reuptake inhibitors
Seriously Prepare Cities for the Flu Vaccine
-Sertaline (Zoloft)
--Paroxetine (Paxil)
-Citolpram(Celexa)
-Escitalopram (Lexapro)
-Fluoxetine HCl (Prozac)
--Fluvoxamine (Luvox)
-(Viibryd)Citol
5 Sanity-Saving Tips for Arguing on the Internet
Previous
Play
Next
Rewind 10 seconds
Move forward 10 seconds
Unmute
0:01
/
1:27
Full screen
SSRI mechanism of action
Blocks the reuptake of serotonin (only serotonin) thus increasing it's effects
All inhibit the serotonin transporter SERT
SSRI side effects
Gastrointestinal disturbances
Sexual dysfunction
Drowsiness / insomnia
Serotonin Syndrome (rare)
SSRI discontinuation
, sx
uMost common side effects include GI upset, sexual dysfunction (30%+!), anxiety, restlessness,
nervousness, insomnia, fatigue or sedation, dizziness
uVery little risk of cardiotoxicity in overdose
uCan develop a discontinuation syndrome with agitation, nausea, disequilibrium and dysphoria
SSRIs treat
anxiety
depression
SSRI discontinuation syndrome
A drug withdrawal syndrome associated with the use of at least some of the SSRI and SNRI
antidepressants.
SSRI discontinuation syndrome symptoms
flu-like symptoms, dizziness, weakness, nausea, fatigue, feelings of "unreality," loss of balance,
light-headedness, "electric-shock" sensations, and other symptoms.
Paroxitine (Paxil) Pros
Short half life with no active metabolite means no build-up (which is good if hypomania
develops)
Sedating properties (dose at night) offers good initial relief from anxiety and insomnia
Paroxitine (Paxil) Cons
Significant CYP2D6 inhibition
Sedating, wt gain, more anticholinergic effects
sexual side effects
Notorious for discontinuation syndrome
Sertraline (Zoloft) Pros
Very weak P450 interactions (only slight CYP2D6)
Short half life with lower build-up of metabolites
Less sedating when compared to paroxetine
Sertraline (Zoloft) Cons
Max absorption requires a full stomach
Increased number of GI adverse drug reactions
