Clinical Chemistry Questions and Answers Rated A

Clinical Chemistry Questions and Answers Rated A - Most cases show an increased LH:FSH ratio - Occasional cases will show hyperprolactinemia Pituitary hormone pathology in polycystic ovarian (aka, Stein-Leventhal) syndrome Hyperandrogenism with chronic anovulation in women with no other cause What is an important hormonal derangement in polycystic ovarian syndrome (aka, Stein-Leventhal syndrome) Substantially elevated estrogen production because of the peripheral conversion of androgens to estrogens In polycystic ovarian (aka, Stein-Leventhal) syndrome, is estrogen production norma, increased, or decreased? CA-125 What serum tumor marker is typically elevated in serous carcinoma (aka, malignant serous tumor) of the ovary? - CEA - CA 19-9 - Inhibin - CA 125 What are some serum tumor markers that are elevated in mucinous carcinoma (aka, malignant mucinous tumor) of the ovary? CA 125 Serum tumor marker that is elevated in most cases of endometrioid adenocarcinoma of the ovary. Elevated serum β-HCG Tumor marker associated with ovarian choriocarcinoma Serum HCG continues to rise after 14 weeks of gestation, when the HCG normally drops. What serum marker is indicative of complete (hydatidiform) mole? Term Definition Screening test for porphyria Urine porphobilinogen - often greater than 10 tiems upper reference limit during attacks of acute porphyrias Acute intermittent porpyhria Which is the most common type of porphyria? Autosomal dominant with incomplete penetrance, making family studies challenging Mode of inheritance of acute intermittent porphyria Absence of porphobilinogen deaminase activity What is the biochemical defect in acute intermittant porphyria? Elevated levels of ALA and porphobilinogen levels in the urine during attacks What is the laboratory method for diagnosing acute intermittent porphyria? Turns read or brown What happens to urine from a patient with acute intermittent porphyria when it is exposed to air? Acute intermittent porpyhria Which is the porphyria that lacks cutaneous manifestations? Autosomal dominant with low penatrance What is