USMLE STEP 1 ANTIBIOTIC Questions and Answers with Complete Solutions 2024

USMLE STEP 1 ANTIBIOTIC Questions and Answers with Complete Solutions 2024 Penicillin mechanism - ANSbinds to penicillin binding proteins in peptidoglycan (blocks transpeptidase crosslinking); activates autolytic enzymes penicillin use - ANSgram positives and syphilis penicillin toxicity - ANShypersensitivity reactions, hemolytic anemia penicillinase resistant penicillins - ANSmethicillin, nafcillin, dicloxacillin penicillinase resistant penicillin use - ANSStaph aureus penicillin resistant penicillin toxicity - ANShypersensitivity; methicillin: interstitial nephritis aminopenicillins - ANSampicillin, amoxacillin aminopenicillin mechanism - ANSsame as penicillin but wider spectrum aminopenicillin use - ANSselect gram positive and negative bacteria--H flu, E coli, Listeria, Proteus, Salmonella, enterococci aminopenicillin toxicity - ANShypersensitivity, ampicillin rash, pseudomembranous colitis antipseudomonal drugs - ANSticarcillin, piperacillin, carbenicillin antipseudomonal mechanism - ANSsame as penicillin; wider spectrum antipseudomonal use - ANSPseudomonas and gram negative rods antipsuedomonal toxicity - ANShypersensitivity reaction beta lactamase inhibitor mechanism - ANSinhibit beta lactamase (protects penicillins from destruction) beta lacatamase drugs - ANSclavulanic acid, sulbactam, tazobactam bacteriostatic antibiotics - ANSerythromycin, clindamycin, sulfamethoxazole, trimethoprim, tetracycline, chloramphenicol bactericidal antibiotics - ANSvancomycin, fluoroquinolones, penicillin, aminoglycosides, cephalosporins, metro