EXAM 4 MEDBIOCHEM 100% CORRECT REVIEW SOLUTION QS&AS

EXAM 4 MEDBIOCHEM 100% CORRECT REVIEW SOLUTION QS&AS Blood specimens for digoxin assays should be obtained between 8 hours or more after drug administration because: - ANS-tissue and serum levels need to reach equilibrium A drug has a half life of hours. If a dose is given every 6 hours, a steady state drug level would usually be achieved in : - ANS-24-42 hours Free therapeutic drug levels are usually higher when serum protein concentrations are below normal. In which of the following conditions would this most likely occur? - ANS-nephrotic syndrome Which of the following factors is not relevant to TDM of ahminoglycosides, antibiotics and vancomycin? - ANS-intestinal absorption The drug procainamide is prescribed to treat cardiac arrhythmia. What biologically active liver metabolite of procainamide is often measured simultaneously ? - ANS-NAPA Cocaine is metabolized to: - ANS-Benzoylecgonine The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of - ANS-marijuana Zinc protoporphyrin or free RBC protoporphyrin measurements are useful to access blood concentrations of: - ANS-lead A carbonate salt used to control manic-depressive disorders is: - ANS-lithium An anti epileptic (or anticonvulsant) used to control seizure disorders is: - ANS-phenytoin A drug that relaxes the smooth muscles of bronchial passages is: - ANS-theophylline A cardiac glycoside that is used in the treatment of CHF and arrhythmias by increasing the force and velocity of myocardial contraction is: - ANS-Digoxin A salicylate level is performed to detect toxicity caused by ingestion excess: - ANS-Aspirin Levels of 8-9% carboxyhemoglobin saturation of whole blood are commonly found in which of the following situations? - ANS-Cigarette smokers Which of the following methods would yield reliable quantification of ethanol in the presence of isopropanol? - ANS-Gas-liquid chromatography Lithium therapy is widely used in the treatment of: - ANS-manic depressive (bipolar) disorder An active metabolite of amitriptyline is : - ANS-nortriptyline Phenobarbital is a metabolite of: - ANS-Primidone Which of the following tests would be particularly useful in determining isopropanol exposure? - ANSSerum osmolality and urine acetone...