NURSE 660 EXAM 4 (With complete solution)

Which medication is contraindicated with liver impairment? correct answers Atomoxine (Straterra) What is one of the birth defects associated with Litihum? correct answers Ebstein's anomaly Which SSRI drug causes cardiovascular malformations in the first trimester of pregnancy? correct answers Paroxetine (Paxil) Mechanism of action of a stimulant for ADHD Methylphenidate and amphetamine? correct answers increases the intrasynaptic levels of both dopamine and norepinephrine What causes nicotine withdrawal symptoms? correct answers Nicotine alpha 4 beta 2 post synaptic receptors desensitizes receptors which leads to addiction. Re-sensitization of the nicotine receptors leads to withdrawal A patient diagnosed with ADHD can't stay focused or solve work-related problems difficulty maintaining attention sustained and problem-solving. What area of the brain is involved? correct answers Dorsal lateral prefontal cortex (CTSC loop) What part of the brain is associated with selective attention? correct answers Dorsal anterior singlunate What part of the brain is associated with hyperactivity? correct answers Prefrontal motor cortex What part of the brain is associated with impulsivity? correct answers Orbitofrontal cortex Atomoxetine (Strattera) lacks abuse potential because of what correct answers increases dopamine in the dorsal prefrontal cortex and not in the nucleus accumbens What fetal malformation does valproate cause? correct answers Spina bifida What region of the brain is hypothesized to cause impulsivity? correct answers ventral striatum What region of the brain controls compulsivity? correct answers Dorsal striatum What is the MOA of atomoxetine (Strattera)? correct answers Selective Norepinephrine Reuptake Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline and may also increase dopamine in profrontal cortex • Blocks norepinephrine reuptake pumps, also known as norepinephrine transporters • Amaloid precursor protein is first cleaved by what enzyme correct answers Alpha-secretase What does paroxetine do to Straterra in the body? correct answers increases the effect of the drug in the body