PMNHP QUESTIONS AND ANSWER
ALREADY PASSED
HLA-B 1502 - ✔✔check for prior to starting carbamazepine o asia patient, FDA required. Increased
risk of SJS in pts with the allele
Medication that can induce Mania: - ✔✔Steroids, Antidepressants in bipolar, isoniazid, disulfiram-
antabase
Medication that can induce depression - ✔✔Beta blockers
Benzos
Antineoplastic drugs, accutane
Steroids
Interferon
Some retroviral drugs
Progesterone
Inhibitors - lower dose of medication - ✔✔Buproprion
Clomipramine - tricyclic
Clarithromycin
Flouroquinolones - levofloxin, cipro, moxifloxin, ofloxacin
Grapefruit jice
Ketoconazole - NIzoral, antifungal
Nefazondome MAOI
SSRI - Fluoxetine, Paroxetine
Sx of lithium toxicity - ✔✔N/V/D, altered mental status, oliguria, ataxia, coarse tremor, arrhythmias,
T-wave flattening
EPS: Dystonia - ✔✔Can be within hours, muscle stiffness, involuntary movements and tics
Give Cogentin, Benadryl
ALREADY PASSED
HLA-B 1502 - ✔✔check for prior to starting carbamazepine o asia patient, FDA required. Increased
risk of SJS in pts with the allele
Medication that can induce Mania: - ✔✔Steroids, Antidepressants in bipolar, isoniazid, disulfiram-
antabase
Medication that can induce depression - ✔✔Beta blockers
Benzos
Antineoplastic drugs, accutane
Steroids
Interferon
Some retroviral drugs
Progesterone
Inhibitors - lower dose of medication - ✔✔Buproprion
Clomipramine - tricyclic
Clarithromycin
Flouroquinolones - levofloxin, cipro, moxifloxin, ofloxacin
Grapefruit jice
Ketoconazole - NIzoral, antifungal
Nefazondome MAOI
SSRI - Fluoxetine, Paroxetine
Sx of lithium toxicity - ✔✔N/V/D, altered mental status, oliguria, ataxia, coarse tremor, arrhythmias,
T-wave flattening
EPS: Dystonia - ✔✔Can be within hours, muscle stiffness, involuntary movements and tics
Give Cogentin, Benadryl
