NUR 641E final Exam Questions and Answers

NUR 641E final Exam Questions and Answers Pharmacokinetics involves - ️️ absorption, distribution, metabolism and elimination). Absorption: - ️️ absorption from the administration site either directly or indirectly into the blood/plasma. Distribution: - ️️ reversibly or irreversibly move from the bloodstream into the interstitial and intracellular Metabolism: - ️️ biotransformed via hepatic metabolism or by other tissues. Elimination: - ️️ tissues. lastly, the drug and its metabolites are eliminated from the body. route of administration with the highest bioavailability - ️️ intravenous; putting entire dose into a patient's vein and bypassing absorption. avoids first-pass metabolism - ️️ Intravenous route administration has variable and erratic absorption. n - ️️ Rectal administration 4. Steady state (SS) - ️️ absorption. n is usually reached within 4-5 half-lives of drug. Half-life of a drug is - ️️ how long it takes for half the drug to be excreted from the body. Determines how frequently the drug must be administered. Predicts how long toxic effects can constant with first-order pharmacokinetics of a drug. Zero-order (nonlinear) pharmacokinetics - ️️ means a drug is metabolized at a constant rate per unit time.