BMTCN - Chapters 7-8 questions and answers graded A+ 2023/2024 already passed

BMTCN - Chapters 7-8What has contributed to the increased number of HSCTs? - correct answer -Treatment of older recipients with reduced-intensity conditioning -Increased number of donors What are the 4 categories of second malignancies? - correct answer 1. Acute leukemia and MDS 2. Lymphoma, including post-transplant lymphoproliferative disorders (PTLDs) 3. Solid tumors 4. Skin cancers (carcinoma) PTLD is the most common second malignancy in the first year following which type of transplant? - correct answer allogeneic HSCT with T cell depleted graft What are the risk factors of PTLD? - correct answer 1. T cell depletion or mismatched or unrelated donor 2. Agents used to prevent GVHD: Busulfan, ATG, mAbs, or TBI 3. Chronic GVHD or EBV Which type of chemo medication has the highest risk for secondary malignancies? - correct answer Alkylating agents - due to their ability to transfer alkyl groups What does EBV put a patient at high risk for? - correct answer PTLD What are the screening methods post-transplant? - correct answer -Colonscopies -Mammogram -Pap smears -EBV titers What are the treatment options for PTLD? - correct answer -EBV specific cytoxoic T cells -mAbs targeted to B cells (Rituxan) -Combination therapy What are the treatment options for secondary MDS or acute leukemia? - correct answer -Chemo -Allo transplant What are the various impairments that HSCT survivors may encounter? - correct answer Musculoskeletal pain, fatigue, altered sexual health, neurocognitive changes, psychological symptoms, financial concerns, inability to work, strained personal relationships, spiritual impariments What is a unique challenge the pediatric population is faced with after transplant? - correct answer School reentry = learning challenges Besides the patient who underwent treatment, who else is at risk for these emotional challenges? - correct answer Siblings and caregivers What are some interventions for these impariments? - correct answer exercise, psych meds, therapy, support groups, education, meditation/coping skills What causes sexual dysfunctions after transplant? - correct answer Damage from preparative regimen to the HPA axis What are interventions that medical personnel can take to ensure that patients are informed about sexuality changes post-transplant? - correct answer Education, include sexual partner, offering hormone replacement therapy, exercise, diet modifications, lubricants, dilators for vaginal patency, pelvic floor muscle exercises, regular GYN exams, topical steroids, topical cyclosporine What are the two nursing societies that create the standards in general and advanced practice oncology nursing? - correct answer ANA and ONS What are the domains of clinical trail nursing? - correct answer clinical practice, human subjects protection, contribution to science, care coordination, and study management