BMTCN
C. Monocytes - correct answer Which of the following is an example of a myeloid cell?
A. t cell
B. b cells
C. monocytes
D. NK cells
B. viral infections - correct answer Several factors affect immune reconstitution following hematopoietic stem cell transplantation. These include all of the following EXCEPT:
A. Recipient's response to conditioning regimen
B. Viral infections
C. Chronic GVHD
D. Longevity of mature lymphocytes present at time of transplant
A. Bone Marrow - correct answer Hematopoiesis primarily occurs in which area?
A. Bone Marrow
B. Spleen
C. Thymus gland
D. Lymph nodes
C - correct answer Which of the following statements is true about innate immunity?
A. It occurs in response to T-cell activation.
B. It occurs in response to B-cell activation.
C. It is a natural process that uses phagocytes that release inflammatory mediators in response to infections or illness.
D. It is a natural process that occurs primarily in the spleen
D. Breast Cancer - correct answer Which is NOT a common indication for allogeneic transplantation? A. AML
B. MDS
C. CML
D. Breast Cancer
C - correct answer GVT effect is promoted by which of the following?
A. Withdrawal of immunosuppressive therapy.
B. Administration of DLI
C. A and B
D. Increased dose of immunosuppressive therapy
D. Recommend over the counter medication for management of post-HSCT symptoms - correct answer Which of the following is NOT a role of a caregiver?
A. Provide physical and emotional support
B. Assist with recovery following HSCT
C. Assist with medication administration
D. Recommend over the counter medication for management of post-HSCT symptoms
D. himself - correct answer M.J. is to undergo an auto transplant. From whom will he receive his stem cells?
A. A matched related donor.
B. A matched unrelated donor.
C. An umbilical cord blood
D. Himself
A. graft failure - correct answer P .F. has undergone an allogeneic transplant using umbilical cord blood as the stem cell source. This makes her at higher risk for which of the following post-transplant complications?
A. Graft failure
B. GVHD C. N/V
D. Complications of surgery
A. umbilical cord and bone marrow - correct answer E.N. is worried about the post-transplant complication of GVHD. Which stem cell sources have recently been shown to have decreased incidence of this serious and often debilitating problem?
A. Umbilical Cord and Bone Marrow
B. PBSCs and UCB
C. Bone marrow and PBSCs
D. None of the above
B. Paresthesia of the mouth and extremities may occur during leukopheresis because the sodium citrate added to the blood to prevent clotting binds ionized calcium, causing serum hypocalcemia. - correct answer S.J. is about to undergo leukopheresis in preparation for autologous transplant. The nurse informs her that she may experience tingling in her lips and extremities during the procedure. Which statement best explains this symptom?
A. Numbness and tingling are signs of a hypersensitivity reaction to the medications commonly used for mobilization.
B. Paresthesia of the mouth and extremities may occur during leukopheresis because the sodium citrate added to the blood to prevent clotting binds ionized calcium, causing serum hypocalcemia.
C. Patients often experience numbness and tingling as a result of the cooling of the blood while circulating in the apheresis machine.
D. Paresthesia of the mouth and extremities is a sign that too much blood is being processed and that the procedure should be stopped.
C. Plerixafor blocks the interaction between the chemokine receptor CXCR4 and stromal-derived factor-
1, causing stem cells to be released from the bone marrow into the circulating blood. - correct answer Plerixafor works to mobilize hematopoietic stem cells by which of the following mechanisms of action?
A. The drop in white blood cells after receiving plerixafor leads to a transient, predictable increase in circulating progenitor cells, which can be collected for HSCT.
B. Plerixafor works by binding to certain cell surface receptors to stimulate the division and differentiation of progenitor stem cells.
C. Plerixafor blocks the interaction between the chemokine receptor CXCR4 and stromal-derived factor-
1, causing stem cells to be released from the bone marrow into the circulating blood. D. Plerixafor is used with chemotherapy to increase the number of circulating progenitor cells.
D. Provide frequent teaching for the donor that is geared toward her developmental level, while giving her the opportunity to ask questions. - correct answer P .J. is a 10 year old female who requires an allogeneic transplant for leukemia. It is determined that the patient's younger sister is a perfect HLA match. Plans are made to begin the collection process as soon as possible. Which of the following is the best strategy for the nurse to support the pediatric donor through the donation process?
A. Direct all teaching efforts to the parents to avoid causing the donor unnecessary stress.
B. Avoid approaching the donor to obtain assent for the procedure because the parents have already given consent and the transplant should take place as soon as possible.
C. Refer to the family psychologist to manage all the donor's psychosocial needs after the transplant has taken place.
D. Provide frequent teaching for the donor that is geared toward her developmental level, while giving her the opportunity to ask questions.
C. It decreases long term side effects - correct answer What is the most important rationale for giving TBI
in multiple fractions?
A. It is easier for patients
B. It decreases short term side effects
C. It decreases long term side effects
D. It is easier for radiation staff
D. B and C - correct answer What change can decrease side effects of busulfan?
A. Using oral busulfan
B. Basing the busulfan dose on blood levels
C. Giving busulfan intravenously
D. B and C
D. Myeloablative Melphalan - correct answer Which regimen is the most appropriate for a 70-year-old patient with MM undergoing an auto SCT?
A. Myeloablative Bu/Cy
B. RIC Melphalan
C. Monocytes - correct answer Which of the following is an example of a myeloid cell?
A. t cell
B. b cells
C. monocytes
D. NK cells
B. viral infections - correct answer Several factors affect immune reconstitution following hematopoietic stem cell transplantation. These include all of the following EXCEPT:
A. Recipient's response to conditioning regimen
B. Viral infections
C. Chronic GVHD
D. Longevity of mature lymphocytes present at time of transplant
A. Bone Marrow - correct answer Hematopoiesis primarily occurs in which area?
A. Bone Marrow
B. Spleen
C. Thymus gland
D. Lymph nodes
C - correct answer Which of the following statements is true about innate immunity?
A. It occurs in response to T-cell activation.
B. It occurs in response to B-cell activation.
C. It is a natural process that uses phagocytes that release inflammatory mediators in response to infections or illness.
D. It is a natural process that occurs primarily in the spleen
D. Breast Cancer - correct answer Which is NOT a common indication for allogeneic transplantation? A. AML
B. MDS
C. CML
D. Breast Cancer
C - correct answer GVT effect is promoted by which of the following?
A. Withdrawal of immunosuppressive therapy.
B. Administration of DLI
C. A and B
D. Increased dose of immunosuppressive therapy
D. Recommend over the counter medication for management of post-HSCT symptoms - correct answer Which of the following is NOT a role of a caregiver?
A. Provide physical and emotional support
B. Assist with recovery following HSCT
C. Assist with medication administration
D. Recommend over the counter medication for management of post-HSCT symptoms
D. himself - correct answer M.J. is to undergo an auto transplant. From whom will he receive his stem cells?
A. A matched related donor.
B. A matched unrelated donor.
C. An umbilical cord blood
D. Himself
A. graft failure - correct answer P .F. has undergone an allogeneic transplant using umbilical cord blood as the stem cell source. This makes her at higher risk for which of the following post-transplant complications?
A. Graft failure
B. GVHD C. N/V
D. Complications of surgery
A. umbilical cord and bone marrow - correct answer E.N. is worried about the post-transplant complication of GVHD. Which stem cell sources have recently been shown to have decreased incidence of this serious and often debilitating problem?
A. Umbilical Cord and Bone Marrow
B. PBSCs and UCB
C. Bone marrow and PBSCs
D. None of the above
B. Paresthesia of the mouth and extremities may occur during leukopheresis because the sodium citrate added to the blood to prevent clotting binds ionized calcium, causing serum hypocalcemia. - correct answer S.J. is about to undergo leukopheresis in preparation for autologous transplant. The nurse informs her that she may experience tingling in her lips and extremities during the procedure. Which statement best explains this symptom?
A. Numbness and tingling are signs of a hypersensitivity reaction to the medications commonly used for mobilization.
B. Paresthesia of the mouth and extremities may occur during leukopheresis because the sodium citrate added to the blood to prevent clotting binds ionized calcium, causing serum hypocalcemia.
C. Patients often experience numbness and tingling as a result of the cooling of the blood while circulating in the apheresis machine.
D. Paresthesia of the mouth and extremities is a sign that too much blood is being processed and that the procedure should be stopped.
C. Plerixafor blocks the interaction between the chemokine receptor CXCR4 and stromal-derived factor-
1, causing stem cells to be released from the bone marrow into the circulating blood. - correct answer Plerixafor works to mobilize hematopoietic stem cells by which of the following mechanisms of action?
A. The drop in white blood cells after receiving plerixafor leads to a transient, predictable increase in circulating progenitor cells, which can be collected for HSCT.
B. Plerixafor works by binding to certain cell surface receptors to stimulate the division and differentiation of progenitor stem cells.
C. Plerixafor blocks the interaction between the chemokine receptor CXCR4 and stromal-derived factor-
1, causing stem cells to be released from the bone marrow into the circulating blood. D. Plerixafor is used with chemotherapy to increase the number of circulating progenitor cells.
D. Provide frequent teaching for the donor that is geared toward her developmental level, while giving her the opportunity to ask questions. - correct answer P .J. is a 10 year old female who requires an allogeneic transplant for leukemia. It is determined that the patient's younger sister is a perfect HLA match. Plans are made to begin the collection process as soon as possible. Which of the following is the best strategy for the nurse to support the pediatric donor through the donation process?
A. Direct all teaching efforts to the parents to avoid causing the donor unnecessary stress.
B. Avoid approaching the donor to obtain assent for the procedure because the parents have already given consent and the transplant should take place as soon as possible.
C. Refer to the family psychologist to manage all the donor's psychosocial needs after the transplant has taken place.
D. Provide frequent teaching for the donor that is geared toward her developmental level, while giving her the opportunity to ask questions.
C. It decreases long term side effects - correct answer What is the most important rationale for giving TBI
in multiple fractions?
A. It is easier for patients
B. It decreases short term side effects
C. It decreases long term side effects
D. It is easier for radiation staff
D. B and C - correct answer What change can decrease side effects of busulfan?
A. Using oral busulfan
B. Basing the busulfan dose on blood levels
C. Giving busulfan intravenously
D. B and C
D. Myeloablative Melphalan - correct answer Which regimen is the most appropriate for a 70-year-old patient with MM undergoing an auto SCT?
A. Myeloablative Bu/Cy
B. RIC Melphalan
