NR 565 MIDTERM FINALS 2023-204

G-Protien coupled receptors and how they interact with drugs - CORRECT ANSWERG-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate the release of G proteins that can interact with various effector proteins to create physiological responses within the body (Insel & Sriram, 2018). This process occurs through secondary messengers (such as cAMP) which creates the extracellular interactions produced by the drug binding to the GRCP.