UTMB ADVANCED PATHOPHYSIOLOGY 5355 Exam 3 QUESTION AND SOLUTIONS 100%

Biogenic Amine Theory linked to depression - Deficiency of neurotransmitters in brain of norepinephrine, dopamine, and/or serotonin. Particularly, a decrease in receptor binding with serotonin. Neurotransmitter Receptor Hypothesis linked to depression - A deficiency of monoamine neurotransmitters at neuronal synapses. Antidepressants increase - Neuronal synaptic levels of monoamine neurotransmitters. if you have more receptors than neurotransmitters - Neurotransmitters do not have time to re-charge thus, they do not function properly. Hypothalamic-Pituitary-Adrenal (HPA) System Dysregulation - HPA system dysregulation with excessive glucocorticoid secretion is found in a large percentage of people suffering from major depression. Patho of Alzheimer's includes - plaque formation, presence of --, with decreased levels of - - Amyloid B, neurofibrillary tangles, acetylcholine these disrupt impulse transmission neurofibrillary tangles - are a deformation of the structure that carries nutrients to neurons of the brain. Decreased levels of choline acetyl transferase and acetylcholine is associated with - Memory loss Most common cause of dementia - Alzheimer's disease fatal 5-10 years Characteristics of Alzheimer's - Loss of memory, language , inability to learn new things, dysfunction, delusions, cannot perform ADLs, majorly effects social life Parkinson's Disease is - Chronic motor progressive neuro-degenerative known as a shaking palsy Parkinson's disease is associated with - basal ganglia dysfunction and atrophy of neurons in the substantia nigra that produce dopamine;