N5315 Advanced Pathophysiology Genetics Core Knowledge Objectives with Advanced Organizers

Genetics Chapter 4 1. Analyze the pathological processes which alter the structure and role of the DNA and RNA molecules. a. Describe the structure and function of the DNA molecule and its clinical significance. PAGE 136-137 i. Four types of nitrogenous bases of DNA include adenine, cytosine, guanine, and thymine commonly represented as their first letter. Physical structure of DNA is the double- helix model which can be envisioned as a twisting ladder with chemical bonds as its rungs. Projecting from each side of the ladder at regular intervals are the nitrogenous bases. The bases projecting from one side is bound to the base projecting from the other by a weak hydrogen bond. Adenine pairs with thymine and Guanine pairs with cytosine. Each DNA subunit consists of one deoxyribose molecule, one phosphate group, and one base called a nucleotide. ii. Function of DNA 1. Genetic code, s