Neurotransmitter Table
* To be completed throughout course and submitted in Week 8*
Neuro Receptor Location/Function/Effects Distribution Drug classes that Specific medications that target this
transmitter Subtype /symptoms of excess or (ie: CNS/PNS, target this neurotransmitter or receptor
deficit if applicable GI, vascular) neurotransmitter or
receptor
Glutamate AMPA Ligand-gated ion channels CNS NMDA glutamate Memantine
Modulates cell excitability antagonist PCP
by allowing the flow of Barbituates Ketamine
calcium and sodium ions Antiepileptics Dextromethorphan
into the cell. Dextromethadone
Located at the CNS in Parampanel
neurons and glia.
Excess has resulted in
schizophrenia, epilepsy,
and mania.
NMDA Ligand-gated ion channels, CNS NMDA receptor Memantine
strengthens synapses and antagonist Amantadine
involved in strong memory Antipsychotics Ketamine
formation. Excess is Loop Diuretics Dextromethorphan
associated with memory Opiates Methadone
and learning impairments, Antidepressants Dextropropoxyphene
psychosis, and excitotoxic Ketobemidone
brain injury. Furosemide
Haldol
Tramadol
GABA GABA a Ligand-gated ion channels CNS Benzodiazepines Lorazepam, Clonazepam, Alprazolam
Functions as postsynaptic Limbic system Hypnotics Zolpidem, Zopiclone, zaleplon
inhibition by CI-influx Striatum Neuroactive steroids Allopregnanolone
Inotropic receptor Medulla
Reduces fear, anxiety, and Spinal Cord
, convulsions Pancreas
GABA b G-Protein Linked CNS/PNS GABA-b receptor Baclofen
Functions as pre-synaptic agonists, Antispastic Arbaclofen
inhibition by lowering Anesthetics Placarbil
calcium ion entry while Propofol
post-synaptic inhibitions
by increasing potassium
ion permeability
Reduces fear, anxiety, and
convulsions
Serotonin 5HT 1a Somatodendritic auto Cerebral Cortex SSRIs, SNRIs, SGAs, Buspirone
5HT receptors Midbrain raphe FGAs, MAOIs, TCAs, Clozapine
Inhibits actions of 5HT Hippocampus Mood stabilizers Trazodone
neurons pre-synaptically Amygdala Lurasidone
and other NTs post- Basal Ganglia Quetiapine
synaptically. Located on Thalamus Valproate
cell body and dendrites in Found on GABA Lithium
the midbrain raphe neurons Brexpiprazole
Targets: anxiety, Aripiprazole
depression, negative Cariprazine
symptoms in Vortioxetene
schizophrenia, decreases
sexual dysfunction and
lack of weight gain with
antidepressants, boosts
actions of SSRIs and SNRIs
5HT 1B Autoreceptor located on CNS, Vascular, Antidepressants Asenapine
the presynaptic axon Cardiac SGAs Vortioxetene
terminal Iloperidone
Acts as negative feedback Clozapine
to detect presence of 5HT, Olanzapine
which decreases further Quetiapine
release of 5HT and Zotepine
neuronal impulse flow and Risperidone
* To be completed throughout course and submitted in Week 8*
Neuro Receptor Location/Function/Effects Distribution Drug classes that Specific medications that target this
transmitter Subtype /symptoms of excess or (ie: CNS/PNS, target this neurotransmitter or receptor
deficit if applicable GI, vascular) neurotransmitter or
receptor
Glutamate AMPA Ligand-gated ion channels CNS NMDA glutamate Memantine
Modulates cell excitability antagonist PCP
by allowing the flow of Barbituates Ketamine
calcium and sodium ions Antiepileptics Dextromethorphan
into the cell. Dextromethadone
Located at the CNS in Parampanel
neurons and glia.
Excess has resulted in
schizophrenia, epilepsy,
and mania.
NMDA Ligand-gated ion channels, CNS NMDA receptor Memantine
strengthens synapses and antagonist Amantadine
involved in strong memory Antipsychotics Ketamine
formation. Excess is Loop Diuretics Dextromethorphan
associated with memory Opiates Methadone
and learning impairments, Antidepressants Dextropropoxyphene
psychosis, and excitotoxic Ketobemidone
brain injury. Furosemide
Haldol
Tramadol
GABA GABA a Ligand-gated ion channels CNS Benzodiazepines Lorazepam, Clonazepam, Alprazolam
Functions as postsynaptic Limbic system Hypnotics Zolpidem, Zopiclone, zaleplon
inhibition by CI-influx Striatum Neuroactive steroids Allopregnanolone
Inotropic receptor Medulla
Reduces fear, anxiety, and Spinal Cord
, convulsions Pancreas
GABA b G-Protein Linked CNS/PNS GABA-b receptor Baclofen
Functions as pre-synaptic agonists, Antispastic Arbaclofen
inhibition by lowering Anesthetics Placarbil
calcium ion entry while Propofol
post-synaptic inhibitions
by increasing potassium
ion permeability
Reduces fear, anxiety, and
convulsions
Serotonin 5HT 1a Somatodendritic auto Cerebral Cortex SSRIs, SNRIs, SGAs, Buspirone
5HT receptors Midbrain raphe FGAs, MAOIs, TCAs, Clozapine
Inhibits actions of 5HT Hippocampus Mood stabilizers Trazodone
neurons pre-synaptically Amygdala Lurasidone
and other NTs post- Basal Ganglia Quetiapine
synaptically. Located on Thalamus Valproate
cell body and dendrites in Found on GABA Lithium
the midbrain raphe neurons Brexpiprazole
Targets: anxiety, Aripiprazole
depression, negative Cariprazine
symptoms in Vortioxetene
schizophrenia, decreases
sexual dysfunction and
lack of weight gain with
antidepressants, boosts
actions of SSRIs and SNRIs
5HT 1B Autoreceptor located on CNS, Vascular, Antidepressants Asenapine
the presynaptic axon Cardiac SGAs Vortioxetene
terminal Iloperidone
Acts as negative feedback Clozapine
to detect presence of 5HT, Olanzapine
which decreases further Quetiapine
release of 5HT and Zotepine
neuronal impulse flow and Risperidone
