,Fever: an elevation of body temperature above the normal range due
to an increase in the hypothalamic set point.
1) pyrogenes microbial products, microbial toxins (endotoxin) or
whole microorganisms
Causes
2) pyrogenic cytokines produced during infection and
inflammatory process IL-1, IL-6, tumor necrosis factor (TNF),
ciliary neurotropic factor (CNTF), and interferon (IFN)
, Rash
is the change of the skin which affects its color, appearance, or texture
It may be due to :
1. Multiplication of infective organism in the skin (e.g. HSV)
2. Toxin produced by organisms acting on skin structures
3. Autoimmune destruction of skin due to inflammatory response
against the infecting microbes
4. Involvement of the vasculature, vasoocclusion, necrosis,
vasodilatation
to an increase in the hypothalamic set point.
1) pyrogenes microbial products, microbial toxins (endotoxin) or
whole microorganisms
Causes
2) pyrogenic cytokines produced during infection and
inflammatory process IL-1, IL-6, tumor necrosis factor (TNF),
ciliary neurotropic factor (CNTF), and interferon (IFN)
, Rash
is the change of the skin which affects its color, appearance, or texture
It may be due to :
1. Multiplication of infective organism in the skin (e.g. HSV)
2. Toxin produced by organisms acting on skin structures
3. Autoimmune destruction of skin due to inflammatory response
against the infecting microbes
4. Involvement of the vasculature, vasoocclusion, necrosis,
vasodilatation
