Dumphy primary care

Dumpy Primary Care
S polycythemia Vera primary or secondary?

Primary -- it is neoplastic proliferation of mature myeloid cells, mainly RBCs




What do labs look like with polycythemia Vera?

Elevated RBC, HGB, HCT




What gene mutation confirms diagnosis in 95% of cases of Polycythemia Vera?

JAK2 V617




Secondary causes of polycythemia Vera?

Smoking, hypoxia, erythropoietin secreting cyst of tumor




Does secondary polycythemia Vera have splenomegaly?

No




What is the clinical presentation of Polycythemia Vera?

-Median age of onset in 60 years old

-More common in men

, -Expanded red cell volume

-Symptoms develop SLOWLY, over time




Does polycythemia Vera cause RBC, HCT, and HGB to be too high or too low?

Too high




Does polycythemia Vera respond to aspirin?

yes it decreases EPO



Does NOT have an effect in secondary polycythemia Vera




Can polycythemia Vera manifest as pulmonary or cardiac disease?

Yes




Patient presents with chest pain, headache, tinnitus, blurred vision, weakness, and malaise? Who am I?

Polycythemia Vera




With polycythemia Vera, pruritus after warm baths is caused by what?

Basophilia releases histamine