CPHON Review: Chemotherapy Review questions with correct answers

Cyclophosphamide - Answer High doses should be preceded and followed by IV hydration and mesna Vincristine - Answer Fatal if administered intrathecally Busulfan - Answer Prophylactic anticonvulsant therapy for patients receiving high doses Busulfan - Answer Requires PK studies Temozolomide - Answer Can only be mixed in applesauce or apple juice Procarbazine - Answer Hypertension and/or CNS depression may occur in the presence of alcohol, (MAO) inhibitors,phenothiazines, dilantin, tricyclic antidepressants, barbiturates and tyramine rich food (aged cheeses, wine, bananas, yogurt and chocolate) Carboplatin - Answer Nephrotoxicity and ototoxicity Oxaliplatin - Answer Avoid cold drinks/food during administration Vincristine - Answer Loss of deep tendon reflexes Constipation