Summary Antigen capture and presentation

How are Antigens Captured and Presented to Cells

Lymph Nodes and the Spleen




 Dendritic cells (Langerhans cell) are antigen presenting cells and work alongside
T cells
 Immature dendritic cells reside in the epidermis whereas mature ones reside in
T cell rich areas of the lymph nodes and spleen

Dendritic Cell Migration

, Antigen Presenting Cells

 Professional APCs like dendritic cells capture bacteria and viruses then
associated their antigens with the MHC molecules




APCs




T Cell Receptors

 TCRs have alpha and beta chains
 Conserved and variable region
 Variable region binds to the antigen
 TCRs only recognise antigens when presented by MHCs

MHC Complex

 Peptide binding cell surface proteins
 MHC in humans=MLA complex
 MHC class I and II
 MHC class I: