ASCP Hematology Revised Test 2023.

ASCP Hematology Revised Test 2023.Name the locations of active marrow in adults: - ANSWERsternum, skull, ribs, pelvis, vertebrae Where does hematopoiesis take place during the first 2 months of gestation? - ANSWERyolk sac Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation? - ANSWERspleen When does the bone marrow take over hematopoiesis? - ANSWERafter birth What are the stages in order of the erythrocyte lineage? - ANSWER(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte, (6)erytrocyte What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage? - ANSWER(1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso What are the stages in order of the macrophage lineage? - ANSWER(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage What are the stages in order of the platelet lineage? - ANSWER(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet What are the stages in order of the lymphocyte lineage? - ANSWER(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte Which growth factors stimulate the erythrocyte lineage? - ANSWERGM-CSF, EPO, IL-3 Which growth factors stimulate the granulocyte lineages? - ANSWERGM-CSF, IL-3 Which growth factors stimulate the platelet lineage? - ANSWERGM-CSF, IL-3, TPO Which growth factors stimulate the lymphocyte lineage? - ANSWERIL-2, IL-4, IL-6, IL-7 Which protein functions in the transport of Fe? - ANSWERtransferrin What is the major storage form of Fe? - ANSWERferritin What is the long-term (H20) insoluble Fe storage form called? - ANSWERhemosiderin Excess Iron is stored where? What does this cause? - ANSWERtissues and body organs, hemosiderosis, hemochromatosis Porphyrias are attributed to? - ANSWERexcessive formation of porphrins due to blockages in any enzymatic step in the heme synthesis pathway