Sickle Cell Anemia questions with correct answers

What is sickle cell anemia? - Answer An autosomal recessive disorder resulting in a mutated form of hemoglobin (HbS) What causes sickle cell TRAIT? - Answer ONE allele on the beta globin gene carries the sickle mutation, one normal allele for HbA (heterozygous) What causes sickle cell DISEASE? - Answer TWO alleles on the beta globin gene carries mutation for sickle mutation (homozygous) What does the sickle cell mutation cause resistance to? - Answer Plasmodium falciparum (malaria) How common is sickle trait and disease in African Americans? - Answer Trait: 1 in 12 Disease: 1 in 500 Newborn screening for sickle cell disorders is optional. True or false? - Answer False (screening is mandatory but parents can opt out) To diagnose sickle trait, what is seen on Hb electrophoresis? - Answer HbA > HbS (50-60% A, 20-45% S) At what age will HbS amounts increase? - A