Nurs 6501 Advance Pathophysiology- Midterm with verified accurate solutions available

Epigenetics Role of Human Development - ANSheritable changes in gene expression or phenotype which is caused by mechanisms other than changes in DNA sequences. -the modification determines the fate of each cell. -DNA sequence remains the same, the transcriptional activity of most genes varies. Prader-Willi Syndrome - ANSInherited 4-Mb deletion chromosome 15 from FATHER. Features include: -short stature -hypotonia (decreased muscle tone) -small hands/feet -obesity -mild-moderate retardation -hypogonadism (lack of hormone secretion). Angelman Syndrome - ANSInherited 4-Mb deletion chromosome 15 from MOTHER. Features include: -severe mental retardation -seizures -ataxic gait MLH1 development role of Inherited Colon Cancer - ANSA major cause of one form of inherited form of colon cancer HNPCC is the methylation of the promoter region of gene, MLH1, whose protein product repairs damaged DNA. -when MLH1 become inactive > damaged DNA accumulates > eventually resulting in colon tumors. Chronic Inflammation can lead to Predisposed Cancers - ANS-Lung Carcinoma (Bronchitis) -Bladder Carcinoma (Cystitis/Bladder Infections) -Colorectal Carcinoma (IBS, Chrons, Colitis) -Oral Carcinoma (Gingivitis) -Pancreatic Carcinoma (Chronic pancreatitis) -Esophageal Carcinoma (Barrett esophagus) -Melanoma (skin inflammation)