N S G
5 3 3
A d v a n c e d
P h a r m a c o l o g y
T e s t
1
W e e k
4
Which
of
the
following
SSRIs
requires
up
to
a
5-week
washout
period
because
of
the
long
half-life
of
its
potent
active
metabolite?
A.
Escitalopram
B.
Fluvoxamine
C.
Fluoxetine
D.
Sertraline
-
ANS
C
Which
of
the
following
symptoms
is
most
likely
to
improve
within
approximately
1
week
of
starting
treatment?
A.
Depressed
mood
B.
Suicidal
thoughts
C.
Anhedonia
D.
Sleep
-
ANS
D
Of
the
following
combinations
of
medications,
which
one
would
you
want
to
avoid? A.
Fluoxetine-lithium
B.
Fluoxetine-phenelzine
C.
Citalopram-valproic
acid
D.
Citalopram-aripiprazole
-
ANS
B
A
26-year-old
man
with
a
history
of
depression
has
been
taking
sertraline
200
mg/day
for
12
weeks
with
no
response.
The
patient
has
no
other
complications.
The
physician
asks
for
your
recommendation.
The
most
reasonable
recommendation
would
be
to:
A.
Increase
sertraline
B.
Add
fluoxetine
C.
Switch
to
amitriptyline
D.
Change
to
venlafaxine
E.
Decrease
sertraline
-
ANS
D
Which
of
the
following
is
a
dangerous
combination?
A.
MAOI-lorazepam
B.
MAOI-acetaminophen
C.
MAOI-meperidine
D.
MAOI-ziprasidone
-
ANS
C
A
23-year-old
married
white
woman
comes
to
the
outpatient
psychiatric
clinic complaining
of
decreased
sleep,
decreased
appetite,
decreased
concentration,
depressed
mood,
thoughts
of
death,
and
lack
of
interest
in
activities
for
6
weeks'
duration.
She
has
no
history
of
psychiatric
illness
and
takes
no
medications
except
for
Ortho-T ri
Cyclen
Lo
daily .
Based
upon
the
patients
symptoms,
choose
the
best
medication
to
treat
this
patient.
A.
Nefazodone
100
mg
po
twice
daily
B.
Paroxetine
20
mg
po
daily
C.
St.
John's
wort
300
mg
po
three
times
daily
D.
Amitriptyline
25
mg
at
bedtime
-
ANS
B
A
36-year-old
man
is
admitted
to
the
hospital
for
a
severe
methicillin-resistant
Staphylococcus
aureus
diabetic
foot
infection
and
is
started
on
linezolid
600
mg
IV
every
12
hours.
His
medication
profile
includes
paroxetine
40
mg
every
morning,
trazodone
100
mg
at
bedtime
as
needed
for
sleep,
and
metformin
1000
mg
po
twice
daily .
After
3
days
on
these
medications,
the
patient
becomes
agitated,
confused,
and
diaphoretic
and
develops
myoclonic
jerks.
Which
of
the
following
is
the
most
likely
diagnosis?
A.
Overdose
of
metformin
B.
Bacterial
meningitis
5 3 3
A d v a n c e d
P h a r m a c o l o g y
T e s t
1
W e e k
4
Which
of
the
following
SSRIs
requires
up
to
a
5-week
washout
period
because
of
the
long
half-life
of
its
potent
active
metabolite?
A.
Escitalopram
B.
Fluvoxamine
C.
Fluoxetine
D.
Sertraline
-
ANS
C
Which
of
the
following
symptoms
is
most
likely
to
improve
within
approximately
1
week
of
starting
treatment?
A.
Depressed
mood
B.
Suicidal
thoughts
C.
Anhedonia
D.
Sleep
-
ANS
D
Of
the
following
combinations
of
medications,
which
one
would
you
want
to
avoid? A.
Fluoxetine-lithium
B.
Fluoxetine-phenelzine
C.
Citalopram-valproic
acid
D.
Citalopram-aripiprazole
-
ANS
B
A
26-year-old
man
with
a
history
of
depression
has
been
taking
sertraline
200
mg/day
for
12
weeks
with
no
response.
The
patient
has
no
other
complications.
The
physician
asks
for
your
recommendation.
The
most
reasonable
recommendation
would
be
to:
A.
Increase
sertraline
B.
Add
fluoxetine
C.
Switch
to
amitriptyline
D.
Change
to
venlafaxine
E.
Decrease
sertraline
-
ANS
D
Which
of
the
following
is
a
dangerous
combination?
A.
MAOI-lorazepam
B.
MAOI-acetaminophen
C.
MAOI-meperidine
D.
MAOI-ziprasidone
-
ANS
C
A
23-year-old
married
white
woman
comes
to
the
outpatient
psychiatric
clinic complaining
of
decreased
sleep,
decreased
appetite,
decreased
concentration,
depressed
mood,
thoughts
of
death,
and
lack
of
interest
in
activities
for
6
weeks'
duration.
She
has
no
history
of
psychiatric
illness
and
takes
no
medications
except
for
Ortho-T ri
Cyclen
Lo
daily .
Based
upon
the
patients
symptoms,
choose
the
best
medication
to
treat
this
patient.
A.
Nefazodone
100
mg
po
twice
daily
B.
Paroxetine
20
mg
po
daily
C.
St.
John's
wort
300
mg
po
three
times
daily
D.
Amitriptyline
25
mg
at
bedtime
-
ANS
B
A
36-year-old
man
is
admitted
to
the
hospital
for
a
severe
methicillin-resistant
Staphylococcus
aureus
diabetic
foot
infection
and
is
started
on
linezolid
600
mg
IV
every
12
hours.
His
medication
profile
includes
paroxetine
40
mg
every
morning,
trazodone
100
mg
at
bedtime
as
needed
for
sleep,
and
metformin
1000
mg
po
twice
daily .
After
3
days
on
these
medications,
the
patient
becomes
agitated,
confused,
and
diaphoretic
and
develops
myoclonic
jerks.
Which
of
the
following
is
the
most
likely
diagnosis?
A.
Overdose
of
metformin
B.
Bacterial
meningitis
