UTHSC Fall 2022 D2 Par 1 Pathology

UTHSC Fall 2022 D2 Par 1 Pathology Pathology the study of disease Pathology consists of what four aspects? - Etiology - Pathogenesis - Molecular and morphologic changes - Clinical manifestations Etiology The cause of the disease or condition - Genetic - Acquired - Ultimately most are multifactorial Pathogenesis The sequence of events from the etiology to clinical expression or manifestations Molecular and morphologic changes Alterations that may be characteristic or diagnostic. Pathology is becoming increasingly involved in the use of molecular or immunologic techniques Clinical manifestations The end results of the disease process what responses will a cell have to severe stress? adapt, undergo injury or die Cellular Adaptations Reversible and structural responses to stresses - Hypertrophy - Hyperplasia - Atrophy - Metaplasia cellular injury May be reversible or irreversible cellular death - Necrosis - Apoptosis Hypertrophy Increase in cell size, resulting in increase in the size of the organ Hypertrophy is caused by increased functional demand or hormonal stimulation Hyperplasia Increase in the number of cells and increased tissue mass T/F hyperplasia may be physiologic but not pathologic False, it can be both