Hematology ASCP BOC| 377 QUESTIONS| WITH COMPLETE SOLUTIONS

The following are compounds formed in the synthesis of heme: 1 coproporphyrinogen 2 porphobilinogen 3 uroporphyrinogen 4 protoporphyrinogen Which of the following responses lists these compounds in the order in which they are formed? Correct Answer: 2, 3, 1, 4 The majority of the iron in an adult is found as a constituent of: Correct Answer: hemoglobin In order for hemoglobin to combine reversibly with oxygen, the iron must be: Correct Answer: in the ferrous state Which description best fits the Donath-Landsteiner antibody? Correct Answer: IgG biphasic hemolysin the abnormal erythrocyte in the center of this image (arrow) may result from which of the following processes? Correct Answer: deficiencies of cellular membrane proteins what is the composition of the inclusion seen in this RBC? Correct Answer: DNA Which of the following ions is bound to hemoglobin in methemoglobin? Correct Answer: Fe3+ An increased amount of cytoplasmic basophilia in a blood cell indicates: Correct Answer: decreased cytoplasmic maturation Specific (secondary) granules of the neutrophilic granulocyte: Correct Answer: appear first at the myelocyte stage In normal adult bone marrow, the most common granulocyte is the? Correct Answer: metamyelocyte Pluripotent hematopoietic stem cells are capable of producing: Correct Answer: lymphoid and myeloid stem cells Which of the following cytokines is most responsible for eosinophil differentiation and release from the bone marrow? Correct Answer: IL-5 Auer rods are characterized as: Correct Answer: DNA precipitates