rheumatoid arthritis (RA)
* chronic , systemic autoimmune disease
years of age
RA 30 and 50 cause is unknown : autoimmunity
*
usually peaks between
* estimated 300 000 Canadians affected genetic factors
* more common in women than men
etiology and pathophysiology
y } É É ÷ ÷ ÷
" " " senor ,.am
Hr
attacks its joint
.
fibrin stage one : the
body mistakenly own
lymphocyte infiltrate tissue
inflamed synovium
soft swelling
tissue
stage two : the
body makes the antibodies and the joints
start
swelling up
fibrin
§]
vascular granulation
" tissue
" " " mm " " "
"
""" " " """ "" "" + " " mi " "+ and deformed
" '
bone
the fingers become crooked . These misshapen
pannus destroys cartilage
joints can press on the nerves and cause
at joint periphery
nerve pain as well .
.É(÷*¥Ñ÷÷÷÷*
loss of bone
density stage four if
:
not treated the disease will progress to
)
.
cartilage
the last stage , in which there is no joint
joint
at all and the joint
* mi erosion of
edges remaining ,
is
essentially
Of bone fused .
. :*
.
due to inflammation and
thickening of synovium and
capsule
* chronic , systemic autoimmune disease
years of age
RA 30 and 50 cause is unknown : autoimmunity
*
usually peaks between
* estimated 300 000 Canadians affected genetic factors
* more common in women than men
etiology and pathophysiology
y } É É ÷ ÷ ÷
" " " senor ,.am
Hr
attacks its joint
.
fibrin stage one : the
body mistakenly own
lymphocyte infiltrate tissue
inflamed synovium
soft swelling
tissue
stage two : the
body makes the antibodies and the joints
start
swelling up
fibrin
§]
vascular granulation
" tissue
" " " mm " " "
"
""" " " """ "" "" + " " mi " "+ and deformed
" '
bone
the fingers become crooked . These misshapen
pannus destroys cartilage
joints can press on the nerves and cause
at joint periphery
nerve pain as well .
.É(÷*¥Ñ÷÷÷÷*
loss of bone
density stage four if
:
not treated the disease will progress to
)
.
cartilage
the last stage , in which there is no joint
joint
at all and the joint
* mi erosion of
edges remaining ,
is
essentially
Of bone fused .
. :*
.
due to inflammation and
thickening of synovium and
capsule
