WEEK 1 PART 2 PHARMACOLOGY PRINCIPLES - PHARMACOKINETICS, DRUG
SAFETY, AN PEDIATRIC CONSIDERATIONS STUDYGUIDE QUESTIONS AND
CORRECT ANSWERS
Question:
1. What is absorption?
Answer:
Movement of a drug from its entry site into the bloodstream.
Question:
2. What is distribution?
Answer:
Movement of a drug from the bloodstream to its site of action.
Question:
3. Which medication route generally has the slowest absorption?
Answer:
The transdermal route.
Question:
4. What enzymes are mainly involved in drug biotransformation?
Answer:
Liver enzymes, especially the cytochrome P450 enzymes.
Question:
5. What can drug accumulation cause?
Answer:
Prolonged drug effects and toxicity.
Question:
6. What is steady state?
Answer:
When the amount of drug absorbed equals the amount eliminated with each dose.
Question:
7. What factors affect drug distribution?
Answer:
Blood flow, body water, body fat, and protein binding.
Question:
8. What is the therapeutic index (TI)?
Answer:
A measurement comparing a drug's effective dose with its toxic dose.
, Question:
9. What does a wide therapeutic index mean?
Answer:
The drug has a larger safety margin and a lower risk of toxicity.
Question:
10. What does a narrow therapeutic index mean?
Answer:
The drug has a small safety margin and requires close monitoring.
Question:
11. Which patients have a higher risk of toxicity? therapeutic index?
Answer:
Neonates, infants, older adults, and patients with liver, kidney, or GI dysfunction.
Question:
12. What is first-pass metabolism?
Answer:
Breakdown of a drug by the liver before it reaches systemic circulation.
Question:
13. Does an IV medication undergo first-pass metabolism?
Answer:
No. It enters the bloodstream directly.
Question:
14. Do IM and subcutaneous medications undergo first-pass metabolism?
Answer:
No. They enter systemic circulation without first passing through the liver.
Question:
15. Do sublingual and buccal medications undergo first-pass metabolism?
Answer:
No. They are absorbed through the oral mucosa into systemic circulation.
Question:
16. Does an oral medication undergo first-pass metabolism?
Answer:
Yes. It travels from the GI tract through the portal vein to the liver.
Question:
17. Do inhaled medications undergo first-pass metabolism?
SAFETY, AN PEDIATRIC CONSIDERATIONS STUDYGUIDE QUESTIONS AND
CORRECT ANSWERS
Question:
1. What is absorption?
Answer:
Movement of a drug from its entry site into the bloodstream.
Question:
2. What is distribution?
Answer:
Movement of a drug from the bloodstream to its site of action.
Question:
3. Which medication route generally has the slowest absorption?
Answer:
The transdermal route.
Question:
4. What enzymes are mainly involved in drug biotransformation?
Answer:
Liver enzymes, especially the cytochrome P450 enzymes.
Question:
5. What can drug accumulation cause?
Answer:
Prolonged drug effects and toxicity.
Question:
6. What is steady state?
Answer:
When the amount of drug absorbed equals the amount eliminated with each dose.
Question:
7. What factors affect drug distribution?
Answer:
Blood flow, body water, body fat, and protein binding.
Question:
8. What is the therapeutic index (TI)?
Answer:
A measurement comparing a drug's effective dose with its toxic dose.
, Question:
9. What does a wide therapeutic index mean?
Answer:
The drug has a larger safety margin and a lower risk of toxicity.
Question:
10. What does a narrow therapeutic index mean?
Answer:
The drug has a small safety margin and requires close monitoring.
Question:
11. Which patients have a higher risk of toxicity? therapeutic index?
Answer:
Neonates, infants, older adults, and patients with liver, kidney, or GI dysfunction.
Question:
12. What is first-pass metabolism?
Answer:
Breakdown of a drug by the liver before it reaches systemic circulation.
Question:
13. Does an IV medication undergo first-pass metabolism?
Answer:
No. It enters the bloodstream directly.
Question:
14. Do IM and subcutaneous medications undergo first-pass metabolism?
Answer:
No. They enter systemic circulation without first passing through the liver.
Question:
15. Do sublingual and buccal medications undergo first-pass metabolism?
Answer:
No. They are absorbed through the oral mucosa into systemic circulation.
Question:
16. Does an oral medication undergo first-pass metabolism?
Answer:
Yes. It travels from the GI tract through the portal vein to the liver.
Question:
17. Do inhaled medications undergo first-pass metabolism?
