P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
NUR 355 Exam 2 MedSurg 1
Questions & Answers for
2026/2027 Medical Surgical
Nursing Comprehensive
Edition (Rationales)
Verified Answers Exam Ready With Rationales 75 QUESTIONS
DOCUMENT OVERVIEW
This comprehensive document contains 75 Medical-Surgical Nursing questions, each with
its correct answer and detailed rationale. It covers essential medical-surgical nursing
concepts, serving as an invaluable resource for students to study, review course material,
and prepare for certification exams by understanding the provided answers and their
explanations.
TOPICS
Inflammatory & Autoimmune Conditions Q1–Q19
Pain Management Q20–Q42
Infection Control & Prevention Q43–Q56
Immunity & Hypersensitivity Q57–Q75
Page 1
, E XA M Q U EST I O N S
Q1 QUESTION 1 OF 75
What would be present in fibromyalgia?
ANSWER
muscle pain and tender points all over without joint edema
RATIONALE
Fibromyalgia is characterized by widespread musculoskeletal pain and the presence of tender
points, which are specific locations of tenderness upon palpation. Unlike inflammatory
arthropathies, joint swelling or edema is typically absent in fibromyalgia. This distinction is key in
differentiating it from other rheumatic conditions.
Q2 QUESTION 2 OF 75
Which labs would be elevated with gout?
ANSWER
Serum uric acid
RATIONALE
Gout is a metabolic disorder characterized by hyperuricemia, which is an elevated level of uric acid
in the blood. This excess uric acid can precipitate as monosodium urate crystals in the joints,
leading to inflammation and pain. Therefore, a serum uric acid level is the primary laboratory
indicator of gout.
Q3 QUESTION 3 OF 75
Clinical manifestations of an acute flare-up of gout?
Page 2
, ANSWER
-Warmth in affected joint
-Elevated serum uric acid level
-Redness in affected joint
-Pain of the affected area
RATIONALE
An acute gout flare-up is an inflammatory response to monosodium urate crystal deposition in a
joint. This deposition triggers vasodilation and increased blood flow, leading to localized warmth
and redness. The inflammatory process also stimulates nociceptors, causing significant pain, and is
associated with hyperuricemia, an elevated serum uric acid level.
Q4 QUESTION 4 OF 75
What is a classic sign of Lupus?
ANSWER
Butterfly rash over cheeks
RATIONALE
A malar rash, often described as a butterfly pattern across the bridge of the nose and cheeks, is a
hallmark dermatologic manifestation of systemic lupus erythematosus. This erythematous eruption
is typically photosensitive and indicates a systemic autoimmune process.
Q5 QUESTION 5 OF 75
Kaposi's sarcoma is associated with what?
ANSWER
potential HIV
Other S&S: age, change in mental status, headache
RATIONALE
Kaposi's sarcoma (KS) is an opportunistic neoplasm strongly linked to human immunodeficiency
virus (HIV) infection. Immunosuppression from HIV facilitates the reactivation of human
herpesvirus 8 (HHV-8), the primary oncogenic agent in KS development. Other signs like altered
mental status can indicate advanced disease or opportunistic infections.
Page 3
NUR 355 Exam 2 MedSurg 1
Questions & Answers for
2026/2027 Medical Surgical
Nursing Comprehensive
Edition (Rationales)
Verified Answers Exam Ready With Rationales 75 QUESTIONS
DOCUMENT OVERVIEW
This comprehensive document contains 75 Medical-Surgical Nursing questions, each with
its correct answer and detailed rationale. It covers essential medical-surgical nursing
concepts, serving as an invaluable resource for students to study, review course material,
and prepare for certification exams by understanding the provided answers and their
explanations.
TOPICS
Inflammatory & Autoimmune Conditions Q1–Q19
Pain Management Q20–Q42
Infection Control & Prevention Q43–Q56
Immunity & Hypersensitivity Q57–Q75
Page 1
, E XA M Q U EST I O N S
Q1 QUESTION 1 OF 75
What would be present in fibromyalgia?
ANSWER
muscle pain and tender points all over without joint edema
RATIONALE
Fibromyalgia is characterized by widespread musculoskeletal pain and the presence of tender
points, which are specific locations of tenderness upon palpation. Unlike inflammatory
arthropathies, joint swelling or edema is typically absent in fibromyalgia. This distinction is key in
differentiating it from other rheumatic conditions.
Q2 QUESTION 2 OF 75
Which labs would be elevated with gout?
ANSWER
Serum uric acid
RATIONALE
Gout is a metabolic disorder characterized by hyperuricemia, which is an elevated level of uric acid
in the blood. This excess uric acid can precipitate as monosodium urate crystals in the joints,
leading to inflammation and pain. Therefore, a serum uric acid level is the primary laboratory
indicator of gout.
Q3 QUESTION 3 OF 75
Clinical manifestations of an acute flare-up of gout?
Page 2
, ANSWER
-Warmth in affected joint
-Elevated serum uric acid level
-Redness in affected joint
-Pain of the affected area
RATIONALE
An acute gout flare-up is an inflammatory response to monosodium urate crystal deposition in a
joint. This deposition triggers vasodilation and increased blood flow, leading to localized warmth
and redness. The inflammatory process also stimulates nociceptors, causing significant pain, and is
associated with hyperuricemia, an elevated serum uric acid level.
Q4 QUESTION 4 OF 75
What is a classic sign of Lupus?
ANSWER
Butterfly rash over cheeks
RATIONALE
A malar rash, often described as a butterfly pattern across the bridge of the nose and cheeks, is a
hallmark dermatologic manifestation of systemic lupus erythematosus. This erythematous eruption
is typically photosensitive and indicates a systemic autoimmune process.
Q5 QUESTION 5 OF 75
Kaposi's sarcoma is associated with what?
ANSWER
potential HIV
Other S&S: age, change in mental status, headache
RATIONALE
Kaposi's sarcoma (KS) is an opportunistic neoplasm strongly linked to human immunodeficiency
virus (HIV) infection. Immunosuppression from HIV facilitates the reactivation of human
herpesvirus 8 (HHV-8), the primary oncogenic agent in KS development. Other signs like altered
mental status can indicate advanced disease or opportunistic infections.
Page 3
