NAPLEX BPH Questions with Correct Answers (Grade A+)
Question 1: The prostate is dependent on ___ for development, size, and function.
Answer: androgens
Question 2: How does prostatic hyperplasia occur?
Answer: increased conversion of testosterone to dihydrotestosterone by 5-alpha reductase
Question 3: LUTS
Answer: lower urinary tract symptoms - frequent urination
Question 4: What causes LUTS in BPH?
Answer: bladder outlet obstruction by the enlarged prostate + increased smooth muscle tone and resistance
Question 5: At what age is BPH usually diagnosed?
Answer: e65yo
Question 6: How is BPH diagnosed?
Answer: physical exam with DRE, urinalysis, and PSA
Question 7: What drugs worsen sx of BPH?
Answer: anticholinergics (antihistamines, decongestants, phenothiazines, TCAs), caffeine, diuretics, SNRIs,
testosterone
Question 8: What are s/sx of BPH?
Answer: hesitancy, intermittent urine flow, weak stream, urgency, leaking, nocturia, incomplete emptying;
severe -> acute renal failure, UTI
Question 9: How is mild BPH treated?
Answer: watchful waiting with annual reassessment
Question 10: How is mod-severe BPH treated?
Answer: alpha-1 blockers, 5AR inhibitors, tadalafil, TURP
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, Question 11: What natural products have been used for BPH?
Answer: saw palmetto, lycopene both have variable evidence
Question 12: Which treatment for BPH works the fastest?
Answer: alpha-1 blockers
Question 13: Which treatment for BPH reduces the size of the prostate?
Answer: 5-alpha reductase inhibitors, but slower onset
Question 14: When are tolterodine or mirabegron used for BPH?
Answer: if elevated post void residual
Question 15: alpha-1 blocker MOA
Answer: inhibit alpha-1 causing relaxation of smooth muscle in the prostate and bladder neck to improve
urinary flow
Question 16: alpha-1A
Answer: in prostate (1B and 1D in heart and arteries)
Question 17: Which drug class causes intraoperative floppy iris syndrome?
Answer: alpha-blockers - terazosin, doxazosin, tamsulosin, carvedilol
Question 18: alpha blocker + tadalafil
Answer: do not use if tadalafil is dosed daily - risk for hypotension
Question 19: Which alpha blocker causes QT prolongation?
Answer: alfuzosin
Question 20: When are 5-alpha reductase inhibitors used?
Answer: add on to alpha blockers
Question 21: finasteride vs. dutasteride
Answer: finasteride is selective for alpha-reductase type II; dutasteride is nonselective
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Question 1: The prostate is dependent on ___ for development, size, and function.
Answer: androgens
Question 2: How does prostatic hyperplasia occur?
Answer: increased conversion of testosterone to dihydrotestosterone by 5-alpha reductase
Question 3: LUTS
Answer: lower urinary tract symptoms - frequent urination
Question 4: What causes LUTS in BPH?
Answer: bladder outlet obstruction by the enlarged prostate + increased smooth muscle tone and resistance
Question 5: At what age is BPH usually diagnosed?
Answer: e65yo
Question 6: How is BPH diagnosed?
Answer: physical exam with DRE, urinalysis, and PSA
Question 7: What drugs worsen sx of BPH?
Answer: anticholinergics (antihistamines, decongestants, phenothiazines, TCAs), caffeine, diuretics, SNRIs,
testosterone
Question 8: What are s/sx of BPH?
Answer: hesitancy, intermittent urine flow, weak stream, urgency, leaking, nocturia, incomplete emptying;
severe -> acute renal failure, UTI
Question 9: How is mild BPH treated?
Answer: watchful waiting with annual reassessment
Question 10: How is mod-severe BPH treated?
Answer: alpha-1 blockers, 5AR inhibitors, tadalafil, TURP
Page 1
, Question 11: What natural products have been used for BPH?
Answer: saw palmetto, lycopene both have variable evidence
Question 12: Which treatment for BPH works the fastest?
Answer: alpha-1 blockers
Question 13: Which treatment for BPH reduces the size of the prostate?
Answer: 5-alpha reductase inhibitors, but slower onset
Question 14: When are tolterodine or mirabegron used for BPH?
Answer: if elevated post void residual
Question 15: alpha-1 blocker MOA
Answer: inhibit alpha-1 causing relaxation of smooth muscle in the prostate and bladder neck to improve
urinary flow
Question 16: alpha-1A
Answer: in prostate (1B and 1D in heart and arteries)
Question 17: Which drug class causes intraoperative floppy iris syndrome?
Answer: alpha-blockers - terazosin, doxazosin, tamsulosin, carvedilol
Question 18: alpha blocker + tadalafil
Answer: do not use if tadalafil is dosed daily - risk for hypotension
Question 19: Which alpha blocker causes QT prolongation?
Answer: alfuzosin
Question 20: When are 5-alpha reductase inhibitors used?
Answer: add on to alpha blockers
Question 21: finasteride vs. dutasteride
Answer: finasteride is selective for alpha-reductase type II; dutasteride is nonselective
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