NAGELHOUT-Pharm 2-Exam 1Questions
with 100% Correct Answers Latest
Version
Ultra short acting neuromuscular blocker
(Length of duration)
Succinylcholine
(5 - 15 minutes)
Depolarizing NMB
Succinylcholine
Intermediate Acting Nondepolarizing NMBs (4)
(Length of duration)
Atracurium
Cisatracurium
Vecuronium
Rocuromium
(30-60 minutes)
Long Acting Nondepolarizing NMB
(Length of duration)
Pancuronium
60-90 minutes
Short Acting Nondepolarizing NMBs
(Length of duration)
None
(20-30 minutes)
NMB Reversal Agents (3)
Neostigmine
Edrophonium
Sugammadex (not approved by FDA)
NMBs work at ____ receptors
Nicotinic Cholinergic (sub-m)
Neurotransmitter of the NM junction
acetylcholine
, Breaks down acetylcholine at the NM synapse/junction
acetylcholinesterase
Non-depolarizing agents are: agonists or antagonists
Antagonist
Depolarizing agents act as: agonist or antagonist??
Agonist then antagonist
Onset time definition
time from drug administration to maximum effect
Clinical duration definition
time from drug administration to 25% recovery of twitch response
Total duration of action definition
time from drug administration to 90% recovery of twitch response
(point at which pt is recovered)
Recovery index definition
time from 25% to 75% recovery of twitch response (how fast?)
Train of Four Index
4th twitch of TOF/1st twitch of TOF
Muscle stimulated by ulnar nerve in TOF
Adductor pollicis
Best nerve/muscle to measure onset of NMB
Facial Nerve
Orbicularis Oculi (Corrugator supercilii = best)
(reflects diaphragm blockade)
Best nerve/muscle to measure emersion from NMB
Ulnar Nerve
Adductor Pollicis
Single Twitch Test
1.0 Hz
Single stimulus
Compares pre (baseline) and post NMB hand twitch
Train of Four Test
4 - 2 Hz twitches
Compares 4th twitch to 1st twitch (fade)
Reflects 70-100% blockade
Double Burst Simulation (DBS) Test
with 100% Correct Answers Latest
Version
Ultra short acting neuromuscular blocker
(Length of duration)
Succinylcholine
(5 - 15 minutes)
Depolarizing NMB
Succinylcholine
Intermediate Acting Nondepolarizing NMBs (4)
(Length of duration)
Atracurium
Cisatracurium
Vecuronium
Rocuromium
(30-60 minutes)
Long Acting Nondepolarizing NMB
(Length of duration)
Pancuronium
60-90 minutes
Short Acting Nondepolarizing NMBs
(Length of duration)
None
(20-30 minutes)
NMB Reversal Agents (3)
Neostigmine
Edrophonium
Sugammadex (not approved by FDA)
NMBs work at ____ receptors
Nicotinic Cholinergic (sub-m)
Neurotransmitter of the NM junction
acetylcholine
, Breaks down acetylcholine at the NM synapse/junction
acetylcholinesterase
Non-depolarizing agents are: agonists or antagonists
Antagonist
Depolarizing agents act as: agonist or antagonist??
Agonist then antagonist
Onset time definition
time from drug administration to maximum effect
Clinical duration definition
time from drug administration to 25% recovery of twitch response
Total duration of action definition
time from drug administration to 90% recovery of twitch response
(point at which pt is recovered)
Recovery index definition
time from 25% to 75% recovery of twitch response (how fast?)
Train of Four Index
4th twitch of TOF/1st twitch of TOF
Muscle stimulated by ulnar nerve in TOF
Adductor pollicis
Best nerve/muscle to measure onset of NMB
Facial Nerve
Orbicularis Oculi (Corrugator supercilii = best)
(reflects diaphragm blockade)
Best nerve/muscle to measure emersion from NMB
Ulnar Nerve
Adductor Pollicis
Single Twitch Test
1.0 Hz
Single stimulus
Compares pre (baseline) and post NMB hand twitch
Train of Four Test
4 - 2 Hz twitches
Compares 4th twitch to 1st twitch (fade)
Reflects 70-100% blockade
Double Burst Simulation (DBS) Test
