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ROSENTHAL BURCHUM
LEHNE’S
PHARMACOTHERAPEUTICS
for Advanced Practice Nurses
and Physician Assistants
Student Resources on Evolve
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2019v1.0
, CONTENTS
UNIT I Introduction 31 Central Nervous System Stimulants and Attention-Deficit/
Hyperactivity Disorder, 246
1 Prescriptive Authority, 1
2 Rational Drug Selection and Prescription Writing, 6 UNIT VIII Substance Use Disorders
3 Promoting Positive Outcomes of Drug Therapy, 10
32 Substance Use Disorders I: Basic Considerations, 253
UNIT II Basic Principles of Pharmacology 33 Substance Use Disorders II: Alcohol, 258
34 Substance Use Disorders III: Nicotine and Smoking, 265
4 Pharmacokinetics, Pharmacodynamics, and Drug 35 Substance Use Disorders IV: Major Drugs of Misuse Other
Interactions, 15 Than Alcohol and Nicotine, 270
5 Adverse Drug Reactions and Medication Errors, 36
6 Individual Variation in Drug Responses, 44 UNIT IX Drugs That Affect the Heart, Blood
7 Genetic and Genomic Considerations in
Pharmacotherapeutics, 48 Vessels, Blood, and Blood Volume
36 Review of Hemodynamics, 281
UNIT III Drug Therapy Across the Life Span 37 Diuretics, 286
38 Drugs Acting on the Renin-Angiotensin-Aldosterone
8 Drug Therapy During Pregnancy and Breastfeeding, 53 System, 293
9 Drug Therapy in Pediatric Patients, 59 39 Calcium Channel Blockers, 304
10 Drug Therapy in Geriatric Patients, 63 40 Vasodilators, 309
41 Drugs for Hypertension, 312
UNIT IV Peripheral Nervous System Drugs 42 Drugs for Heart Failure, 321
43 Antidysrhythmic Drugs, 333
11 Basic Principles of Neuropharmacology, 69 44 Prophylaxis of Atherosclerotic Cardiovascular Disease:
12 Physiology of the Peripheral Nervous System, 73 Drugs That Help Normalize Cholesterol and Triglyceride
13 Muscarinic Agonists and Cholinesterase Inhibitors, 83 Levels, 345
14 Muscarinic Antagonists, 92 45 Drugs for Angina Pectoris, 360
15 Adrenergic Agonists, 100 46 Anticoagulant and Antiplatelet Drugs, 368
16 Adrenergic Antagonists, 109 47 Drugs for Deficiency Anemias, 385
17 Indirect-Acting Antiadrenergic Agents, 120
UNIT X Drugs for Endocrine Disorders
UNIT V Central Nervous System Drugs
48 Drugs for Diabetes, 393
18 Introduction to Central Nervous System 49 Drugs for Thyroid Disorders, 416
Pharmacology, 125
19 Drugs for Parkinson Disease, 127 UNIT XI Reproductive Health
20 Drugs for Alzheimer Disease, 144
21 Drugs for Seizure Disorders, 152 50 Estrogens and Progestins: Basic Pharmacology and
22 Drugs for Muscle Spasm and Spasticity, 169 Noncontraceptive Applications, 425
51 Birth Control, 437
UNIT VI Drugs for Pain 52 Androgens, 447
53 Drugs for Benign Prostatic Hyperplasia, 453
23 Local Anesthetics, 177 54 Drugs for Sexual Dysfunction, 457
24 Opioid Analgesics, Opioid Antagonists, and Nonopioid 55 Transgender Health, 466
Centrally Acting Analgesics, 181
25 Drugs for Headache, 192 UNIT XII Antiinflammatory, Antiallergic,
and Immunologic Drugs
UNIT VII Psychotherapeutic Drugs
56 Review of the Immune System, 475
26 Antipsychotic Agents and Their Use in Schizophrenia, 201 57 Childhood Immunization, 484
27 Antidepressants, 212 58 Antihistamines, 495
28 Drugs for Bipolar Disorder, 226 59 Cyclooxygenase Inhibitors, Nonsteroidal
29 Sedative-Hypnotic Drugs, 232 Antiinflammatory Drugs, and Acetaminophen, 500
30 Management of Anxiety Disorders, 241 60 Glucocorticoids in Nonendocrine Disorders, 510
, UNIT XIII Drugs for Bone and Joint Disorders 77 Sulfonamide Antibiotics and Trimethoprim, 682
78 Drug Therapy for Urinary Tract Infections, 689
61 Drug Therapy for Rheumatoid Arthritis, 519 79 Drug Therapy for Tuberculosis, 694
62 Drug Therapy for Gout, 534 80 Miscellaneous Antibacterial Drugs, 707
63 Drugs Affecting Calcium Levels and Bone 81 Antifungal Agents, 711
Mineralization, 540 82 Antiviral Agents I: Drugs for Non-HIV Viral Infections, 721
83 Antiviral Agents II: Drugs for HIV Infection, 745
84 Drug Therapy for Sexually Transmitted Infections, 764
UNIT XIV Respiratory Tract Drugs 85 Anthelmintics, 773
64 Drugs for Asthma and Chronic Obstructive Pulmonary
Disease, 557 UNIT XVIII Cancer Therapy
65 Drugs for Allergic Rhinitis, Cough, and Colds, 577
86 Introduction to Immunomodulators, 779
87 Supportive Care of Patients Receiving Anticancer
UNIT XV Gastrointestinal Drugs Drugs, 782
66 Drugs for Peptic Ulcer Disease, 585 88 Drugs for Cancer Pain, 811
67 Laxatives, 594
68 Other Gastrointestinal Drugs, 601 UNIT XIX Drugs for Eyes, Ears, and Skin
89 Drugs for Disorders of the Eye, 819
UNIT XVI Nutrition and Complementary Therapies 90 Drugs for Disorders of the Skin, 830
69 Vitamins, 611 91 Drugs for Disorders of the Ear, 855
70 Drugs for Obesity, 621
71 Complementary and Alternative Therapy, 630 UNIT XX Drug Therapy in Acute Care
92 Agents Affecting the Volume and Ion Content of Body
UNIT XVII Therapy for Infectious and Parasitic Fluids, 863
Diseases 93 Management of ST-Elevation Myocardial Infarction, 867
94 Drugs for Acute Care, 872
72 Basic Principles of Antimicrobial Therapy, 645
73 Drugs That Weaken the Bacterial Cell Wall I:
Penicillins, 656 Appendix: Canadian Drug Information, 883
74 Drugs That Weaken the Bacterial Cell Wall II:
Other Drugs, 663 Index, 887
75 Bacteriostatic Inhibitors of Protein Synthesis, 670
76 Aminoglycosides: Bactericidal Inhibitors of Protein
Synthesis, 677
ROSENTHAL BURCHUM
LEHNE’S
PHARMACOTHERAPEUTICS
for Advanced Practice Nurses
and Physician Assistants
Student Resources on Evolve
Evolve *
Access Code Inside
,YOU’VE JUST PURCHASED
MORE THAN
A TEXTBOOK!
Enhance your learning with Evolve Student Resources.
These online study tools and exercises can help deepen your
understanding of textbook content so you can be more
prepared for class, perform better on exams, and succeed
in your course.
Activate the complete learning experience that comes with each
NEW textbook purchase by registering with your scratch-o access code at
http://evolve.elsevier.com/Rosenthal/pharmacotherapeutics/
If your school uses its own Learning Management System, your resources may be
delivered on that platform. Consult with your instructor.
If you rented or purchased a used book and the scratch-o code at right
has already been revealed, the code may have been used and cannot
be re-used for registration. To purchase a new code to access these
Place
valuable study resources, simply follow the link above.
Sticker
Here
REGISTER TODAY!
You can now purchase Elsevier products on Evolve!
Go to evolve.elsevier.com/shop to search and browse for products.
2019v1.0
, CONTENTS
UNIT I Introduction 31 Central Nervous System Stimulants and Attention-Deficit/
Hyperactivity Disorder, 246
1 Prescriptive Authority, 1
2 Rational Drug Selection and Prescription Writing, 6 UNIT VIII Substance Use Disorders
3 Promoting Positive Outcomes of Drug Therapy, 10
32 Substance Use Disorders I: Basic Considerations, 253
UNIT II Basic Principles of Pharmacology 33 Substance Use Disorders II: Alcohol, 258
34 Substance Use Disorders III: Nicotine and Smoking, 265
4 Pharmacokinetics, Pharmacodynamics, and Drug 35 Substance Use Disorders IV: Major Drugs of Misuse Other
Interactions, 15 Than Alcohol and Nicotine, 270
5 Adverse Drug Reactions and Medication Errors, 36
6 Individual Variation in Drug Responses, 44 UNIT IX Drugs That Affect the Heart, Blood
7 Genetic and Genomic Considerations in
Pharmacotherapeutics, 48 Vessels, Blood, and Blood Volume
36 Review of Hemodynamics, 281
UNIT III Drug Therapy Across the Life Span 37 Diuretics, 286
38 Drugs Acting on the Renin-Angiotensin-Aldosterone
8 Drug Therapy During Pregnancy and Breastfeeding, 53 System, 293
9 Drug Therapy in Pediatric Patients, 59 39 Calcium Channel Blockers, 304
10 Drug Therapy in Geriatric Patients, 63 40 Vasodilators, 309
41 Drugs for Hypertension, 312
UNIT IV Peripheral Nervous System Drugs 42 Drugs for Heart Failure, 321
43 Antidysrhythmic Drugs, 333
11 Basic Principles of Neuropharmacology, 69 44 Prophylaxis of Atherosclerotic Cardiovascular Disease:
12 Physiology of the Peripheral Nervous System, 73 Drugs That Help Normalize Cholesterol and Triglyceride
13 Muscarinic Agonists and Cholinesterase Inhibitors, 83 Levels, 345
14 Muscarinic Antagonists, 92 45 Drugs for Angina Pectoris, 360
15 Adrenergic Agonists, 100 46 Anticoagulant and Antiplatelet Drugs, 368
16 Adrenergic Antagonists, 109 47 Drugs for Deficiency Anemias, 385
17 Indirect-Acting Antiadrenergic Agents, 120
UNIT X Drugs for Endocrine Disorders
UNIT V Central Nervous System Drugs
48 Drugs for Diabetes, 393
18 Introduction to Central Nervous System 49 Drugs for Thyroid Disorders, 416
Pharmacology, 125
19 Drugs for Parkinson Disease, 127 UNIT XI Reproductive Health
20 Drugs for Alzheimer Disease, 144
21 Drugs for Seizure Disorders, 152 50 Estrogens and Progestins: Basic Pharmacology and
22 Drugs for Muscle Spasm and Spasticity, 169 Noncontraceptive Applications, 425
51 Birth Control, 437
UNIT VI Drugs for Pain 52 Androgens, 447
53 Drugs for Benign Prostatic Hyperplasia, 453
23 Local Anesthetics, 177 54 Drugs for Sexual Dysfunction, 457
24 Opioid Analgesics, Opioid Antagonists, and Nonopioid 55 Transgender Health, 466
Centrally Acting Analgesics, 181
25 Drugs for Headache, 192 UNIT XII Antiinflammatory, Antiallergic,
and Immunologic Drugs
UNIT VII Psychotherapeutic Drugs
56 Review of the Immune System, 475
26 Antipsychotic Agents and Their Use in Schizophrenia, 201 57 Childhood Immunization, 484
27 Antidepressants, 212 58 Antihistamines, 495
28 Drugs for Bipolar Disorder, 226 59 Cyclooxygenase Inhibitors, Nonsteroidal
29 Sedative-Hypnotic Drugs, 232 Antiinflammatory Drugs, and Acetaminophen, 500
30 Management of Anxiety Disorders, 241 60 Glucocorticoids in Nonendocrine Disorders, 510
, UNIT XIII Drugs for Bone and Joint Disorders 77 Sulfonamide Antibiotics and Trimethoprim, 682
78 Drug Therapy for Urinary Tract Infections, 689
61 Drug Therapy for Rheumatoid Arthritis, 519 79 Drug Therapy for Tuberculosis, 694
62 Drug Therapy for Gout, 534 80 Miscellaneous Antibacterial Drugs, 707
63 Drugs Affecting Calcium Levels and Bone 81 Antifungal Agents, 711
Mineralization, 540 82 Antiviral Agents I: Drugs for Non-HIV Viral Infections, 721
83 Antiviral Agents II: Drugs for HIV Infection, 745
84 Drug Therapy for Sexually Transmitted Infections, 764
UNIT XIV Respiratory Tract Drugs 85 Anthelmintics, 773
64 Drugs for Asthma and Chronic Obstructive Pulmonary
Disease, 557 UNIT XVIII Cancer Therapy
65 Drugs for Allergic Rhinitis, Cough, and Colds, 577
86 Introduction to Immunomodulators, 779
87 Supportive Care of Patients Receiving Anticancer
UNIT XV Gastrointestinal Drugs Drugs, 782
66 Drugs for Peptic Ulcer Disease, 585 88 Drugs for Cancer Pain, 811
67 Laxatives, 594
68 Other Gastrointestinal Drugs, 601 UNIT XIX Drugs for Eyes, Ears, and Skin
89 Drugs for Disorders of the Eye, 819
UNIT XVI Nutrition and Complementary Therapies 90 Drugs for Disorders of the Skin, 830
69 Vitamins, 611 91 Drugs for Disorders of the Ear, 855
70 Drugs for Obesity, 621
71 Complementary and Alternative Therapy, 630 UNIT XX Drug Therapy in Acute Care
92 Agents Affecting the Volume and Ion Content of Body
UNIT XVII Therapy for Infectious and Parasitic Fluids, 863
Diseases 93 Management of ST-Elevation Myocardial Infarction, 867
94 Drugs for Acute Care, 872
72 Basic Principles of Antimicrobial Therapy, 645
73 Drugs That Weaken the Bacterial Cell Wall I:
Penicillins, 656 Appendix: Canadian Drug Information, 883
74 Drugs That Weaken the Bacterial Cell Wall II:
Other Drugs, 663 Index, 887
75 Bacteriostatic Inhibitors of Protein Synthesis, 670
76 Aminoglycosides: Bactericidal Inhibitors of Protein
Synthesis, 677
