Path 370 Week 2.Final Test 2026\2027.
Examples of type I hypersensitivity
drug reactions, rhinitis, atopic eczema, bee sting reactions, and asthma.
What does the kidney secrete?
erythropoietin
How is type II hypersensitivity initiated?
Cell lysis may be mediated by (IgM or IgG) activated
complement fragments (membrane attack complex) or
by phagocytic cells that are attracted to target cells by
the attached antibodies.
How Is Type IV hypersensitivity initiated?
Sensitized T cells react with altered or foreign cells and initiate inflammation in the dermal
regions.
How long does Type II Hypersensitivity occur?
Occurs within 15-30 mins
Examples of Type II Hypersensitivity
transfusion reactions,
erythroblastosis fetalis, myasthenia gravis, and
hyperacute graft rejection.
Type III Hypersensitivity
(Immune Complex/Arthus Reaction) reactions occur when antigen-antibody complexes are
deposited in tissues and result in the activation of complement and subsequent tissue
inflammation and destruction
How is Type III hypersensitivity initiated?
Mediated by IgG. Antigen-antibody complexes
activate the complement cascade and subsequently attract phagocytic cells to the tissue.
History of persistent low-grade infections, inhalation of antigens into alveoli, and
autoimmune production of antibodies may result in chronic production of antigen-antibody
complexes.
, Path 370 Week 2.Final Test 2026\2027.
How long does Type III hypersensitivity occur?
Occurs in 6 hours
How is Type I hypersensitivity initiated?
initiated when IgE antibodies located on the mast cell membrane are bound by antigen, with
subsequent cross-linking of IgE receptors. Mast cell degranulation releases chemicals that
mediate the signs and symptoms of anaphylaxis.
Type II Hypersensitivity
(cytotoxic or cytolytic) occurs when antibodies are formed against antigens on cell
surfaces, usually resulting in lysis of target cells.
Type IV Hypersensitivity
(delayed-hypersensivity) reactions are T-cell mediated and do not require antibody
production, in contrast to type I, II, and III reactions.
How long does type IV hypersensitivity occur?
Occurs in 24-48 hours
Examples of type IV hypersensitivity
Contact dermatitis, tuberculin reactions, transplant
rejection, and graft-versus-host disease, Guillain
Barre disease, and Multiple Sclerosis
Type I hypersensitivity
(atopic or anaphylactic)
is an immediate allergic or anaphylactic type of reaction mediated primarily by sensitized
mast cells
Varicose Veins
blood pools in superficial vein in calf
Organ that makes clotting factors
Liver (stores vitamin K that helps with blood clots)
Necessary for RBC Production?
Iron
How is CO2 transported in the blood?
As a bicarbonate ion
How long does type I hypersensitivity occur?
Examples of type I hypersensitivity
drug reactions, rhinitis, atopic eczema, bee sting reactions, and asthma.
What does the kidney secrete?
erythropoietin
How is type II hypersensitivity initiated?
Cell lysis may be mediated by (IgM or IgG) activated
complement fragments (membrane attack complex) or
by phagocytic cells that are attracted to target cells by
the attached antibodies.
How Is Type IV hypersensitivity initiated?
Sensitized T cells react with altered or foreign cells and initiate inflammation in the dermal
regions.
How long does Type II Hypersensitivity occur?
Occurs within 15-30 mins
Examples of Type II Hypersensitivity
transfusion reactions,
erythroblastosis fetalis, myasthenia gravis, and
hyperacute graft rejection.
Type III Hypersensitivity
(Immune Complex/Arthus Reaction) reactions occur when antigen-antibody complexes are
deposited in tissues and result in the activation of complement and subsequent tissue
inflammation and destruction
How is Type III hypersensitivity initiated?
Mediated by IgG. Antigen-antibody complexes
activate the complement cascade and subsequently attract phagocytic cells to the tissue.
History of persistent low-grade infections, inhalation of antigens into alveoli, and
autoimmune production of antibodies may result in chronic production of antigen-antibody
complexes.
, Path 370 Week 2.Final Test 2026\2027.
How long does Type III hypersensitivity occur?
Occurs in 6 hours
How is Type I hypersensitivity initiated?
initiated when IgE antibodies located on the mast cell membrane are bound by antigen, with
subsequent cross-linking of IgE receptors. Mast cell degranulation releases chemicals that
mediate the signs and symptoms of anaphylaxis.
Type II Hypersensitivity
(cytotoxic or cytolytic) occurs when antibodies are formed against antigens on cell
surfaces, usually resulting in lysis of target cells.
Type IV Hypersensitivity
(delayed-hypersensivity) reactions are T-cell mediated and do not require antibody
production, in contrast to type I, II, and III reactions.
How long does type IV hypersensitivity occur?
Occurs in 24-48 hours
Examples of type IV hypersensitivity
Contact dermatitis, tuberculin reactions, transplant
rejection, and graft-versus-host disease, Guillain
Barre disease, and Multiple Sclerosis
Type I hypersensitivity
(atopic or anaphylactic)
is an immediate allergic or anaphylactic type of reaction mediated primarily by sensitized
mast cells
Varicose Veins
blood pools in superficial vein in calf
Organ that makes clotting factors
Liver (stores vitamin K that helps with blood clots)
Necessary for RBC Production?
Iron
How is CO2 transported in the blood?
As a bicarbonate ion
How long does type I hypersensitivity occur?
