NSG5002 COMPREHENSIVE EXAM
QUESTIONS AND CORRECT ANSWERS
STUDY GUIDE
●● A hypersensitivity reaction that produces an allergic response is
called:
Answer: Anaphylaxis
●● The common hay fever allergy is expressed through a reaction that is
mediated by which class of immunoglobulins?
Answer: IgE
●● Which type of antibody is involved in type I hypersensitivity
reaction?
Answer: IgE
●● Blood transfusion reactions are an example of:
Answer: Alloimmunity
●● During an IgE-mediated hypersensitivity reaction, which leukocyte
is activated?
Answer: c.
Eosinophils
,●● During an IgE-mediated hypersensitivity reaction, the degranulation
of mast cells is a result of which receptor action?
Answer: Histamine bound to H2
●● What characteristic do atopic individuals have that make them
genetically predisposed to develop allergies?
Answer: c.
Greater quantities of IgE
●● What is the mechanism that results in type II hypersensitivity
reactions?
Answer: d.
Antibodies bind to the antigens on the cell surface.
●● When mismatched blood is administered causing an ABO
incompatibility, the erythrocytes are destroyed by
Answer: a.
Complement-mediated cell lysis
●● When antibodies are formed against red blood cell antigens of the Rh
system, the blood cells are destroyed by:
Answer: Phagocytosis in the spleen
,●● When soluble antigens from infectious agents enter circulation,
tissue damage is a result of:
Answer: d.
Neutrophil granules and toxic oxygen products
●● How are target cells destroyed in a type II hypersensitivity reaction?
Answer: d.
Natural killer cells
●● Graves disease (hyperthyroidism) is an example of which type II
hypersensitivity reaction?
Answer: Modulation
●● Type III hypersensitivity reactions are a result of which of the
following?
Answer: b.
Antibodies binding to soluble antigens that were released into body
fluids and the immune complexes being deposited in the tissues
●● A type IV hypersensitivity reaction causes which result?
Answer: .
, Lymphokine-producing Th1 cells directly attacking and destroying
cellular targets
●● In a type III hypersensitivity reaction, the harmful effects after the
immune complexes that are deposited in tissues are a result of:
Answer: Complement activation
●● Raynaud phenomenon is classified as a type III hypersensitivity
reaction and is due to:
Answer: a.
Immune complexes that are deposited in capillary beds, blocking
circulation
●● Deficiencies in which element can produce depression of both B-
and T-cell function?
Answer: Zinc
●● When the maternal immune system becomes sensitized against
antigens expressed by the fetus, what reaction occurs?
Answer: Alloimmunity
●● Tissue damage caused by the deposition of circulating immune
complexes containing an antibody against the host DNA is the cause of
which disease?
QUESTIONS AND CORRECT ANSWERS
STUDY GUIDE
●● A hypersensitivity reaction that produces an allergic response is
called:
Answer: Anaphylaxis
●● The common hay fever allergy is expressed through a reaction that is
mediated by which class of immunoglobulins?
Answer: IgE
●● Which type of antibody is involved in type I hypersensitivity
reaction?
Answer: IgE
●● Blood transfusion reactions are an example of:
Answer: Alloimmunity
●● During an IgE-mediated hypersensitivity reaction, which leukocyte
is activated?
Answer: c.
Eosinophils
,●● During an IgE-mediated hypersensitivity reaction, the degranulation
of mast cells is a result of which receptor action?
Answer: Histamine bound to H2
●● What characteristic do atopic individuals have that make them
genetically predisposed to develop allergies?
Answer: c.
Greater quantities of IgE
●● What is the mechanism that results in type II hypersensitivity
reactions?
Answer: d.
Antibodies bind to the antigens on the cell surface.
●● When mismatched blood is administered causing an ABO
incompatibility, the erythrocytes are destroyed by
Answer: a.
Complement-mediated cell lysis
●● When antibodies are formed against red blood cell antigens of the Rh
system, the blood cells are destroyed by:
Answer: Phagocytosis in the spleen
,●● When soluble antigens from infectious agents enter circulation,
tissue damage is a result of:
Answer: d.
Neutrophil granules and toxic oxygen products
●● How are target cells destroyed in a type II hypersensitivity reaction?
Answer: d.
Natural killer cells
●● Graves disease (hyperthyroidism) is an example of which type II
hypersensitivity reaction?
Answer: Modulation
●● Type III hypersensitivity reactions are a result of which of the
following?
Answer: b.
Antibodies binding to soluble antigens that were released into body
fluids and the immune complexes being deposited in the tissues
●● A type IV hypersensitivity reaction causes which result?
Answer: .
, Lymphokine-producing Th1 cells directly attacking and destroying
cellular targets
●● In a type III hypersensitivity reaction, the harmful effects after the
immune complexes that are deposited in tissues are a result of:
Answer: Complement activation
●● Raynaud phenomenon is classified as a type III hypersensitivity
reaction and is due to:
Answer: a.
Immune complexes that are deposited in capillary beds, blocking
circulation
●● Deficiencies in which element can produce depression of both B-
and T-cell function?
Answer: Zinc
●● When the maternal immune system becomes sensitized against
antigens expressed by the fetus, what reaction occurs?
Answer: Alloimmunity
●● Tissue damage caused by the deposition of circulating immune
complexes containing an antibody against the host DNA is the cause of
which disease?
