ABCP PERFUSION BASIC SCIENCE Questions and Answers Verified
Solutions Latest Update
Question: Hyperthermia
Answer:
It's an autosomal defect of Ryanodine subtype 1 receptor, RY1 on chromosome 19
Question: RY1 responsible for?
Answer:
Contraction and coupling in skeletal muscle
Question: Hyperthermia?
Answer:
Depolarizing muscle relaxants: succinylcholine and hologenated inhalation gases
Question: What is the most common need for surgery during pregnancy?
Answer:
MS (mitral stenosis)
Question: What is optimal timing for pregnant pt?
Answer:
2Nd trimester (14-26 wks) because fetus organs are formed and fetus maybe viable.
Question: CPB?
Answer:
Maintain fetal oxygenation, MAP>50mmHg, 2. 5 L/min desirable (70 and up to 3. 4 L/min can be
good)
Question: What type of flow is preferable for pregnant pts?
Answer:
Pulsitile flow prevents drop in UBF and limits rise in uterine vascular resistance (UVR)
Question: What temp should a pregnant patient be kept?
Answer:
Maintain 35+ degrees because hypothermia decreases O2 exchange through placenta, provokes uterine
contractions and decreases placental BF
, Question: Sickle cell disease
Answer:
1) Don't induce sickle cell crisis via HYPOXIA, VASCULAR STASIS, HYPEROSMOLARITY,
ACIDOSIS
2) Avoid hyperthermia: causes vasoconstriction, venous stasis
3) Only crystalloid CPG to flush HbS from coronaries
Question: Methemoglobinemia?
Answer:
Draw arterial and venous blood gases to rule out oxygenator
Question: How do you treat methemoglobinemia?
Answer:
1-2Mg/kg methylene blue 1% soln: converts MetHB to OxyHB
Question: Which allows for 10X increase in O2 carrying capacity?
Answer:
Question: Thalassemia pt
Answer:
For signs of hemolysis
Question: Elliptocytosis?
Answer:
Increases hemolysis, platelet destruction, and protein denaturation
Question: What's treatment for vWF?
Answer:
DDAVP 0. 2-3 mcg/kg over 30 mins
Question: DDAVP?
Answer:
Give factor VIII concentrates or cryp 1 unit/kg may be needed
Question: A (classic hemophilia)
Answer:
DDAVP for mild to moderate hemophila
A. otherwise VIII conc
Solutions Latest Update
Question: Hyperthermia
Answer:
It's an autosomal defect of Ryanodine subtype 1 receptor, RY1 on chromosome 19
Question: RY1 responsible for?
Answer:
Contraction and coupling in skeletal muscle
Question: Hyperthermia?
Answer:
Depolarizing muscle relaxants: succinylcholine and hologenated inhalation gases
Question: What is the most common need for surgery during pregnancy?
Answer:
MS (mitral stenosis)
Question: What is optimal timing for pregnant pt?
Answer:
2Nd trimester (14-26 wks) because fetus organs are formed and fetus maybe viable.
Question: CPB?
Answer:
Maintain fetal oxygenation, MAP>50mmHg, 2. 5 L/min desirable (70 and up to 3. 4 L/min can be
good)
Question: What type of flow is preferable for pregnant pts?
Answer:
Pulsitile flow prevents drop in UBF and limits rise in uterine vascular resistance (UVR)
Question: What temp should a pregnant patient be kept?
Answer:
Maintain 35+ degrees because hypothermia decreases O2 exchange through placenta, provokes uterine
contractions and decreases placental BF
, Question: Sickle cell disease
Answer:
1) Don't induce sickle cell crisis via HYPOXIA, VASCULAR STASIS, HYPEROSMOLARITY,
ACIDOSIS
2) Avoid hyperthermia: causes vasoconstriction, venous stasis
3) Only crystalloid CPG to flush HbS from coronaries
Question: Methemoglobinemia?
Answer:
Draw arterial and venous blood gases to rule out oxygenator
Question: How do you treat methemoglobinemia?
Answer:
1-2Mg/kg methylene blue 1% soln: converts MetHB to OxyHB
Question: Which allows for 10X increase in O2 carrying capacity?
Answer:
Question: Thalassemia pt
Answer:
For signs of hemolysis
Question: Elliptocytosis?
Answer:
Increases hemolysis, platelet destruction, and protein denaturation
Question: What's treatment for vWF?
Answer:
DDAVP 0. 2-3 mcg/kg over 30 mins
Question: DDAVP?
Answer:
Give factor VIII concentrates or cryp 1 unit/kg may be needed
Question: A (classic hemophilia)
Answer:
DDAVP for mild to moderate hemophila
A. otherwise VIII conc
