MANAGEMENT OF SEPSIS QUESTIONS WITH DETAILED
VERIFIED AND 100% ACCURATE ANSWERS
Describe the Epidemiology of sepsis and MRO. Correct Answers 1.) In-
hospital mortality is decreasing
2.) Prevalence of severe sepsis is increasing
What are the risk factors of sepsis? Correct Answers
In general, what is the Pathophysiology of sepsis? Correct Answers
Bacterial pathogens activate macrophages to release cytokines
What are the main components of the Pathophysiology of sepsis?
Correct Answers 1.) Pro-inflammatory response
2.) Anti-inflammatory response
3.) Coagulation cascade activation
What causes the Pro-inflammatory response of sepsis? Correct Answers
1.) TNF-α, IL-1, IL-4 cause endothelial cell damage
2.) Increased nitric oxide synthase
The Pro-inflammatory response of sepsis leads to what? Correct
Answers 1.) Capillary fluid leak
2.) Vasodilation
, What causes the anti-inflammatory response of sepsis? Correct Answers
IL-1RA, IL-4, IL-10
The Anti-inflammatory response of sepsis leads to what? Correct
Answers Immunosuppression
What causes the Coagulation cascade activation of sepsis? Correct
Answers 1.) Tissue factor mediated
2.) Impaired anticoagulant and fibrinolysis pathways
The Coagulation cascade activation of sepsis leads to what? Correct
Answers Microvascular thrombosis
Overall, sepsis can lead to what? Correct Answers 1.) Tissue
hypoperfusion
2.) Organ dysfunction and failure
3.) Death
What is the SIRS Criteria? Correct Answers 1.) Temp: > 380 C or < 360
C
2.) RR: > 20 br/min or PaCO2 < 32
3.) HR: > 90 bpm
4.) WBC: >12,000, < 4,000, or > 10% bands
VERIFIED AND 100% ACCURATE ANSWERS
Describe the Epidemiology of sepsis and MRO. Correct Answers 1.) In-
hospital mortality is decreasing
2.) Prevalence of severe sepsis is increasing
What are the risk factors of sepsis? Correct Answers
In general, what is the Pathophysiology of sepsis? Correct Answers
Bacterial pathogens activate macrophages to release cytokines
What are the main components of the Pathophysiology of sepsis?
Correct Answers 1.) Pro-inflammatory response
2.) Anti-inflammatory response
3.) Coagulation cascade activation
What causes the Pro-inflammatory response of sepsis? Correct Answers
1.) TNF-α, IL-1, IL-4 cause endothelial cell damage
2.) Increased nitric oxide synthase
The Pro-inflammatory response of sepsis leads to what? Correct
Answers 1.) Capillary fluid leak
2.) Vasodilation
, What causes the anti-inflammatory response of sepsis? Correct Answers
IL-1RA, IL-4, IL-10
The Anti-inflammatory response of sepsis leads to what? Correct
Answers Immunosuppression
What causes the Coagulation cascade activation of sepsis? Correct
Answers 1.) Tissue factor mediated
2.) Impaired anticoagulant and fibrinolysis pathways
The Coagulation cascade activation of sepsis leads to what? Correct
Answers Microvascular thrombosis
Overall, sepsis can lead to what? Correct Answers 1.) Tissue
hypoperfusion
2.) Organ dysfunction and failure
3.) Death
What is the SIRS Criteria? Correct Answers 1.) Temp: > 380 C or < 360
C
2.) RR: > 20 br/min or PaCO2 < 32
3.) HR: > 90 bpm
4.) WBC: >12,000, < 4,000, or > 10% bands