Alpha,..Blockers
• Block,..alpha,..receptors,..on,..blood,..vessels,..(dila
te,..blood,..vessels)
• Therapeutic,.. Uses
o Essential,..Hypertension
• Adverse,..effects
o Orthostatic,..Hypotension
▪ Take,..first,..dose,..sitting,..down
▪ Dangle,..feet,..before,..getting,..up
o Reflex,..tachycardia
o Nasal,..congestion
o Inhibition,..of,..ejaculation
• Doxazosin,..(Cardura)
o Can,..treat,..urinary,..problems,..as,..well
ACE,..Inhibitors 3-5
• Blocks,..angiotensin,..I,..from,..catalyzing,..to,..angiotensi
n,..II
o Prevents,..vasoconstriction
• Therapeutic,.. uses
o HTN
o Heart,..failure
o MI
o Diabetic,..and,..non-diabetic,..nephropathy
o Prevention,..of,..MI,,..stroke,,..and,..death,..in,..patie
nts,..with,..high,..CV,..risk
o Diabetic,..retinopathy
• Adverse,..effects
o Cough
▪ Dry,..hacking,..cough;,..will,..stop,..ACE,..i
nhibitors
▪ Notify,..the,..prescriber
o Hyperkalemia
o First,..dose,..hypotension
o Renal,..failure
▪ BUN,,..creatinine
o Angioedema
▪ Respiratory,..emergency
o ACE,..Inhibitors,..contraindicated,..in,..2nd,.
rd
.and,..3 ,..trimesters
• Contraindications
, o Diuretics-lower,..bp,..too,..much
o Antihypertensive,..agents-,..lower,..bp,..too,..much
o Drugs,..that,..raise,..potassium,..levels
o Lithium-kidneys,..hold,..on,..too,..more,..lithium
o NSAIDs-not,..as,..effective
• Administration
o Po,..without,..regard,..to,..meals
o Captopril,..(Capoten)
o Enalapril,..(Vasotec)
o Enalaprilat,..(Vasotec),..IV,..form
o Fosinopril
o Monopril
o Lisinopril,..(Prinvil),..(Zestril)
ARB
• Prevents,..angiotensin,..II,..from,..binding,..to,..receptors,,..
blocking,..vasoconstricting,..(Angiotensin,..receptor,..
blocker)
• Angiotensin,..II,..is,..made,..but,..ARB,..blocks,..is,..from,..receptor
• Decreases,..peripheral,..vascular,..resistance
• Doesn’t,..cause,..cough,..or,..hyperkalemia
• Therapeutic,.. uses
o HTN
o Heart,..failure
o MI
o Diabetic,..nephropathy
o Stroke,..prevention
o Prevention,..of,..MI,,..stroke,,..and,..death,..in,..patie
nts,..with,..high,..CV,..risk
o Diabetic,..retinopathy
• Adverse,..effects
o Angioedema,..(Swollen,..lips)
▪ Stop,..med,,..seek,..treatment,..immediately
o ARB’s,..contraindicated,..in,..2nd,..and,..3rd,..trimesters
o Renal,..failure
• Administration
o Available,..po,..with,..or,..without,..food
o Losartan,..(Cozaar)
o Irbesartan,..(Avapro)
o Candesartan,..(Atacand)
CA,..Channel,..Blockers g,..cells
• Prevent,..calcium,..from,..enterin