AOCNP review ) Latest recent and frequently
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,the risk for significant bone marrow suppression (8) - correct ans:advanced age (>65),poor nutritional
status, preexisting autoimmune disease, DM, GI disorders, liver disease, or hematopoietic disease, and
substance abuse.
Cancer-induced bone marrow suppression (3) - correct ans:a) dysfunctional hematopoietic cell within
the bone marrow, b) bone marrow infiltration with tumor c)general exhaustion of bone marrow
reserves
solid tumor malignancies with the highest propensity to infiltrate the bone marrow in the course of
metastasis - correct ans:melanoma, cancer of the breast, lung, kidney and prostate
Nitrosoureas (Carmustine, Lomustine) - correct ans:affect the pluripotent stem cell (affecting all cell
lines/cell cycle nonspecific agent) use for glioblastoma multiforme
severe myelosuppression may last up to 85 days, nadir of carmustine occurs in 26-60 days
Radiation induced bone marrow suppression occurs when (2) - correct ans:1. treatment field involves
marrow producing tissue or with dose greater than 15 Gy
CD 4 counts < 500/mm3 - correct ans:significant risk factor for oopotunisitic infections
Cyclosphosphamide - myelosuppression risk - correct ans:moderate
Paclitaxel - myelosuppression risk - correct ans:moderate
Doxorubicin (Adriamycin) - myelosuppression risk - correct ans:alkylating agnet, may produce severe
myelosuppression, the duration only about 21 days
Myelosupression secondary to radiation therapy peaks at - correct ans:week 3
Suppression may occur in all cell lines simultaneously rather than sequentially as seen with
chemotherapy
The recovery period also may be less predictable.
, Second malignancy : Acute leukemia - potential etiologic factor ? - correct ans:Alkylating agent,
especially with high doses or cumulative doses of antimetabolites
Antitumor antibiotics
Corticosteroids
Epipodophyllotoxins (i.e Etoposide)
Second malignancy : Bladder cancer- potential etiologic factor ? - correct ans:radiation therapy for
prostate cancer
Second malignancy : Brain tumors - potential etiologic factor ? - correct ans:therapeutic radiation for
other cancer
Second malignancy : hepatoma- potential etiologic factor ? - correct ans:Androgen therapy
Second malignancy : Kidney cancer - potential etiologic factor ? - correct ans:Brain tumor therapies
Cisplatin, especially in treatment for testicular cancer
Second malignancy : Leukemia - potential etiologic factor ? - correct ans:Antitumor antibiotics
Brest cancer treatment
Lymphoma treatment
Post transplant immunosuppression
Prostate cancer treatment
Second malignancy : Lung cancer - potential etiologic factor ? - correct ans:HIV infection
Theraputic radiation for other cancers
Second malignancy : Mesothelioma - potential etiologic factor ? - correct ans:Thoracic radiation for lung
neoplasms
tested exam with comprehensive questions
and verified accurate solution (detailed &
elaborated) GRADED A+
Professional Academic Assistance Services
Services Offered
Proctored Exam Assistance
Online Class Management (Full Course Support)
Exam Preparation & Study Materials
Assignments and Coursework Support
Essays and Research Papers
Discussion Posts and Replies
CONTACT INFORMATION
WHATAPPSLINK- https://wa.me/254784769540
,the risk for significant bone marrow suppression (8) - correct ans:advanced age (>65),poor nutritional
status, preexisting autoimmune disease, DM, GI disorders, liver disease, or hematopoietic disease, and
substance abuse.
Cancer-induced bone marrow suppression (3) - correct ans:a) dysfunctional hematopoietic cell within
the bone marrow, b) bone marrow infiltration with tumor c)general exhaustion of bone marrow
reserves
solid tumor malignancies with the highest propensity to infiltrate the bone marrow in the course of
metastasis - correct ans:melanoma, cancer of the breast, lung, kidney and prostate
Nitrosoureas (Carmustine, Lomustine) - correct ans:affect the pluripotent stem cell (affecting all cell
lines/cell cycle nonspecific agent) use for glioblastoma multiforme
severe myelosuppression may last up to 85 days, nadir of carmustine occurs in 26-60 days
Radiation induced bone marrow suppression occurs when (2) - correct ans:1. treatment field involves
marrow producing tissue or with dose greater than 15 Gy
CD 4 counts < 500/mm3 - correct ans:significant risk factor for oopotunisitic infections
Cyclosphosphamide - myelosuppression risk - correct ans:moderate
Paclitaxel - myelosuppression risk - correct ans:moderate
Doxorubicin (Adriamycin) - myelosuppression risk - correct ans:alkylating agnet, may produce severe
myelosuppression, the duration only about 21 days
Myelosupression secondary to radiation therapy peaks at - correct ans:week 3
Suppression may occur in all cell lines simultaneously rather than sequentially as seen with
chemotherapy
The recovery period also may be less predictable.
, Second malignancy : Acute leukemia - potential etiologic factor ? - correct ans:Alkylating agent,
especially with high doses or cumulative doses of antimetabolites
Antitumor antibiotics
Corticosteroids
Epipodophyllotoxins (i.e Etoposide)
Second malignancy : Bladder cancer- potential etiologic factor ? - correct ans:radiation therapy for
prostate cancer
Second malignancy : Brain tumors - potential etiologic factor ? - correct ans:therapeutic radiation for
other cancer
Second malignancy : hepatoma- potential etiologic factor ? - correct ans:Androgen therapy
Second malignancy : Kidney cancer - potential etiologic factor ? - correct ans:Brain tumor therapies
Cisplatin, especially in treatment for testicular cancer
Second malignancy : Leukemia - potential etiologic factor ? - correct ans:Antitumor antibiotics
Brest cancer treatment
Lymphoma treatment
Post transplant immunosuppression
Prostate cancer treatment
Second malignancy : Lung cancer - potential etiologic factor ? - correct ans:HIV infection
Theraputic radiation for other cancers
Second malignancy : Mesothelioma - potential etiologic factor ? - correct ans:Thoracic radiation for lung
neoplasms
