HESI RN PHARMACOLOGY ACCURATE PRACTICE
EXAM WITH ALL POSSIBLE APPROVED WELL
ELABORATED PRACTICE QUESTIONS AND 100%
CORRECT VERIFIED ANSWERS WITH DETAILED
RATIONALES PLUS EXPERT ANSWER KEY (100%
CORRECT VERIFIED SOLUTIONS) 2026-2027
CURRENTLY UPDATED VERSION Q&A
GUARANTEED PASS A+ INSTANT DOWNLOAD PDF
1. A client with heart failure is prescribed digoxin.
Which finding indicates a therapeutic response to
the medication?
A. Heart rate of 110 beats per minute
B. Decreased shortness of breath
C. Jugular venous distention
D. Weight gain of 2 pounds in 2 days
Answer: B. Rationale: Digoxin increases the force
of myocardial contraction, leading to increased
cardiac output. A therapeutic response is indicated
,by improved signs of heart failure, such as
decreased dyspnea, edema, and fatigue.
Tachycardia, JVD, and weight gain are signs of
worsening failure or toxicity.
2. A nurse is preparing to administer heparin
subcutaneously. Which action is correct?
A. Aspirate before injection
B. Massage the site after injection
C. Use a 25-gauge, 5/8-inch needle
D. Administer in the deltoid muscle
Answer: C. Rationale: Heparin is administered
subcutaneously using a small-gauge needle (25-26
gauge) and a short length (5/8 inch). Do not
aspirate or massage the site to prevent hematoma
formation. The abdomen is the preferred site.
3. A client is taking warfarin and has an INR of 5.2.
The nurse should anticipate an order for which
medication?
A. Protamine sulfate
B. Vitamin K
C. Naloxone
,D. Flumazenil
Answer: B. Rationale: Vitamin K is the specific
antagonist for warfarin and is used to reverse
excessive anticoagulation (INR > 5.0). Protamine
sulfate reverses heparin. Naloxone reverses
opioids. Flumazenil reverses benzodiazepines.
4. A client prescribed lisinopril reports a persistent,
dry cough. What is the nurse's best response?
A. "This is an expected side effect that will subside."
B. "This indicates an allergic reaction and you
should stop the drug."
C. "This is a common side effect and may require a
change in medication."
D. "Take an over-the-counter cough syrup to
suppress the cough."
Answer: C. Rationale: A persistent, dry, non-
productive cough is a common side effect of ACE
inhibitors (like lisinopril) due to the accumulation
of bradykinin. It is not an allergic reaction but
often leads to a change to an ARB if bothersome.
, 5. The healthcare provider orders furosemide 40
mg IV push. Which laboratory value should the
nurse monitor most closely?
A. Serum sodium
B. Serum potassium
C. Serum calcium
D. Serum glucose
Answer: B. Rationale: Furosemide is a loop diuretic
that inhibits sodium and chloride reabsorption in
the ascending loop of Henle. It causes significant
potassium wasting, making hypokalemia a primary
concern. Monitor potassium levels closely.
6. A client with tuberculosis is prescribed rifampin.
What essential client teaching should the nurse
provide?
A. "Take this medication with a full glass of milk."
B. "Your urine, sweat, and tears may turn a red-
orange color."
C. "You must avoid exposure to direct sunlight."
D. "You will need monthly hearing tests."
Answer: B. Rationale: Rifampin commonly causes a
harmless red-orange discoloration of bodily fluids
EXAM WITH ALL POSSIBLE APPROVED WELL
ELABORATED PRACTICE QUESTIONS AND 100%
CORRECT VERIFIED ANSWERS WITH DETAILED
RATIONALES PLUS EXPERT ANSWER KEY (100%
CORRECT VERIFIED SOLUTIONS) 2026-2027
CURRENTLY UPDATED VERSION Q&A
GUARANTEED PASS A+ INSTANT DOWNLOAD PDF
1. A client with heart failure is prescribed digoxin.
Which finding indicates a therapeutic response to
the medication?
A. Heart rate of 110 beats per minute
B. Decreased shortness of breath
C. Jugular venous distention
D. Weight gain of 2 pounds in 2 days
Answer: B. Rationale: Digoxin increases the force
of myocardial contraction, leading to increased
cardiac output. A therapeutic response is indicated
,by improved signs of heart failure, such as
decreased dyspnea, edema, and fatigue.
Tachycardia, JVD, and weight gain are signs of
worsening failure or toxicity.
2. A nurse is preparing to administer heparin
subcutaneously. Which action is correct?
A. Aspirate before injection
B. Massage the site after injection
C. Use a 25-gauge, 5/8-inch needle
D. Administer in the deltoid muscle
Answer: C. Rationale: Heparin is administered
subcutaneously using a small-gauge needle (25-26
gauge) and a short length (5/8 inch). Do not
aspirate or massage the site to prevent hematoma
formation. The abdomen is the preferred site.
3. A client is taking warfarin and has an INR of 5.2.
The nurse should anticipate an order for which
medication?
A. Protamine sulfate
B. Vitamin K
C. Naloxone
,D. Flumazenil
Answer: B. Rationale: Vitamin K is the specific
antagonist for warfarin and is used to reverse
excessive anticoagulation (INR > 5.0). Protamine
sulfate reverses heparin. Naloxone reverses
opioids. Flumazenil reverses benzodiazepines.
4. A client prescribed lisinopril reports a persistent,
dry cough. What is the nurse's best response?
A. "This is an expected side effect that will subside."
B. "This indicates an allergic reaction and you
should stop the drug."
C. "This is a common side effect and may require a
change in medication."
D. "Take an over-the-counter cough syrup to
suppress the cough."
Answer: C. Rationale: A persistent, dry, non-
productive cough is a common side effect of ACE
inhibitors (like lisinopril) due to the accumulation
of bradykinin. It is not an allergic reaction but
often leads to a change to an ARB if bothersome.
, 5. The healthcare provider orders furosemide 40
mg IV push. Which laboratory value should the
nurse monitor most closely?
A. Serum sodium
B. Serum potassium
C. Serum calcium
D. Serum glucose
Answer: B. Rationale: Furosemide is a loop diuretic
that inhibits sodium and chloride reabsorption in
the ascending loop of Henle. It causes significant
potassium wasting, making hypokalemia a primary
concern. Monitor potassium levels closely.
6. A client with tuberculosis is prescribed rifampin.
What essential client teaching should the nurse
provide?
A. "Take this medication with a full glass of milk."
B. "Your urine, sweat, and tears may turn a red-
orange color."
C. "You must avoid exposure to direct sunlight."
D. "You will need monthly hearing tests."
Answer: B. Rationale: Rifampin commonly causes a
harmless red-orange discoloration of bodily fluids
