NURS 6512 Exam 1 | NURS 6512 Advanced
Pharmacology | Actual Q&A with Rationale (NURS
6512 Exam 1) | Walden
Section A: Multiple Choice (30 questions)
Q1. Which phase of pharmacokinetics involves the movement of a drug from the site of
administration into the bloodstream?
A. Distribution
B. Absorption ✅
C. Metabolism
D. Excretion
Rationale: Absorption is the process by which a drug enters the systemic circulation
from its administration site.
Q2. Which route of administration has the highest bioavailability?
A. Oral
B. Sublingual
C. Intravenous ✅
D. Topical
Rationale: IV administration delivers the drug directly into the bloodstream, bypassing
absorption and first-pass metabolism, resulting in 100% bioavailability.
,Q3. First-pass metabolism primarily occurs in which organ?
A. Kidneys
B. Lungs
C. Liver ✅
D. Heart
Rationale: After oral absorption, drugs travel via the portal vein to the liver, where they
may be extensively metabolized before reaching systemic circulation.
Q4. Which term describes the fraction of an administered dose that reaches systemic
circulation unchanged?
A. Half-life
B. Bioavailability ✅
C. Volume of distribution
D. Clearance
Rationale: Bioavailability (F) is the fraction of the administered dose that reaches the
systemic circulation intact.
Q5. Which type of drug-receptor interaction produces a maximal response even at low
doses?
A. Partial agonist
B. Full agonist ✅
, C. Antagonist
D. Inverse agonist
Rationale: A full agonist binds to a receptor and produces the maximum possible
response.
Q6. Which drug property determines the volume of distribution (Vd)?
A. Protein binding and lipid solubility ✅
B. Rate of renal excretion
C. First-pass metabolism
D. Bioavailability
Rationale: Vd is influenced by how extensively a drug distributes into tissues, which
depends on protein binding and lipid solubility.
Q7. Which enzyme system is primarily responsible for phase I drug metabolism?
A. CYP450 ✅
B. Glucuronosyltransferase
C. Acetyltransferase
D. Sulfotransferase
Rationale: The cytochrome P450 (CYP450) family catalyzes oxidation, reduction, and
hydrolysis reactions in phase I metabolism.
Q8. Which schedule of controlled substances has the highest potential for abuse and
Pharmacology | Actual Q&A with Rationale (NURS
6512 Exam 1) | Walden
Section A: Multiple Choice (30 questions)
Q1. Which phase of pharmacokinetics involves the movement of a drug from the site of
administration into the bloodstream?
A. Distribution
B. Absorption ✅
C. Metabolism
D. Excretion
Rationale: Absorption is the process by which a drug enters the systemic circulation
from its administration site.
Q2. Which route of administration has the highest bioavailability?
A. Oral
B. Sublingual
C. Intravenous ✅
D. Topical
Rationale: IV administration delivers the drug directly into the bloodstream, bypassing
absorption and first-pass metabolism, resulting in 100% bioavailability.
,Q3. First-pass metabolism primarily occurs in which organ?
A. Kidneys
B. Lungs
C. Liver ✅
D. Heart
Rationale: After oral absorption, drugs travel via the portal vein to the liver, where they
may be extensively metabolized before reaching systemic circulation.
Q4. Which term describes the fraction of an administered dose that reaches systemic
circulation unchanged?
A. Half-life
B. Bioavailability ✅
C. Volume of distribution
D. Clearance
Rationale: Bioavailability (F) is the fraction of the administered dose that reaches the
systemic circulation intact.
Q5. Which type of drug-receptor interaction produces a maximal response even at low
doses?
A. Partial agonist
B. Full agonist ✅
, C. Antagonist
D. Inverse agonist
Rationale: A full agonist binds to a receptor and produces the maximum possible
response.
Q6. Which drug property determines the volume of distribution (Vd)?
A. Protein binding and lipid solubility ✅
B. Rate of renal excretion
C. First-pass metabolism
D. Bioavailability
Rationale: Vd is influenced by how extensively a drug distributes into tissues, which
depends on protein binding and lipid solubility.
Q7. Which enzyme system is primarily responsible for phase I drug metabolism?
A. CYP450 ✅
B. Glucuronosyltransferase
C. Acetyltransferase
D. Sulfotransferase
Rationale: The cytochrome P450 (CYP450) family catalyzes oxidation, reduction, and
hydrolysis reactions in phase I metabolism.
Q8. Which schedule of controlled substances has the highest potential for abuse and
