NURS 5463 Module 5: Sepsis
Study online at https://quizlet.com/_c1dntq
1. Old sepsis defini- SIRS
tion Sepsis
Severe sepsis
Septic shock
2. New sepsis defin- Sepsis
ition Septic shock
3. Sepsis Life-threatening organ dysfunction caused by a dysregulated host response to
infection
4. qSOFA Mental status
Systolic blood pressure < 100
Respiratory rate > 22
5. Immune dysreg- Overproduction of cells which can amplify the inflammatory response because of
ulation the attraction of pro-inflammatory cells
6. Metabolic Hyperglycemia
changes Cellular glucose overload and severe oxidative stress leads to endothelial dysfunc-
tion and decreased neutrophil function
Can also damage mitochondria due to oxidative stress
7. Mitochondrial Results in loss of vascular tone, vasodilation, fluid redistribution
dysfunction Microvascular shunting leading to hypoxia
8. Epithelial dys- Allows movement of fluids between barriers which results in increased capillary
function leakage
9. Coagulation acti- Pro-inflammatory and further perpetuates immune response
vation
10. Lactic acid
1/4
Study online at https://quizlet.com/_c1dntq
1. Old sepsis defini- SIRS
tion Sepsis
Severe sepsis
Septic shock
2. New sepsis defin- Sepsis
ition Septic shock
3. Sepsis Life-threatening organ dysfunction caused by a dysregulated host response to
infection
4. qSOFA Mental status
Systolic blood pressure < 100
Respiratory rate > 22
5. Immune dysreg- Overproduction of cells which can amplify the inflammatory response because of
ulation the attraction of pro-inflammatory cells
6. Metabolic Hyperglycemia
changes Cellular glucose overload and severe oxidative stress leads to endothelial dysfunc-
tion and decreased neutrophil function
Can also damage mitochondria due to oxidative stress
7. Mitochondrial Results in loss of vascular tone, vasodilation, fluid redistribution
dysfunction Microvascular shunting leading to hypoxia
8. Epithelial dys- Allows movement of fluids between barriers which results in increased capillary
function leakage
9. Coagulation acti- Pro-inflammatory and further perpetuates immune response
vation
10. Lactic acid
1/4
