NR 601
Final Exam Prep
Test Bank
A+ Verified - Passing Score 80% - 6 Domains
Comprehensive 300-Question Practice Exam with Answer Key
2026-2027 Edition
For Educational Use Only | Not for Distribution
,Sections Covered
Section 1: Health Assessment (50 Questions)
Section 2: Pharmacology (50 Questions)
Section 3: Cardiovascular / Pulmonary (50 Questions)
Section 4: GI / Endocrine / Renal (50 Questions)
Section 5: Neuro / Musculoskeletal / Integumentary (50 Questions)
Section 6: Women's Health / OB-GYN (50 Questions)
Answer key is provided at the end of this document.
,1. A 19-year-old college student presents with sore throat, fever, and tender anterior cervical lymphadenopathy.
There is tonsillar exudate and no cough. What is the most appropriate next step?
A. Rapid strep antigen test
B. Start amoxicillin empirically
C. Monospot test
D. Throat culture only
2. A 36-year-old woman presents with a palpable breast mass that is firm, immobile, and painless.
Mammography shows a spiculated mass with microcalcifications. What is the most appropriate next step?
A. Core needle biopsy
B. Ultrasound-guided aspiration
C. Excisional biopsy
D. Repeat mammography in 6 months
3. A 74-year-old man with atrial fibrillation presents with acute onset of severe abdominal pain out of proportion
to exam findings. He has nausea and bloody diarrhea. What is the most likely diagnosis?
A. Acute mesenteric ischemia
B. Acute diverticulitis
C. Small bowel obstruction
D. Appendicitis
4. A 22-year-old woman presents with low-grade fever, malar rash, and arthritis in her hands and knees.
Laboratory studies show positive ANA, positive anti-dsDNA, and low complement levels. What is the
diagnosis?
A. Systemic lupus erythematosus
B. Rheumatoid arthritis
C. Mixed connective tissue disease
D. Dermatomyositis
5. A 41-year-old woman presents with recurrent urinary tract infections. She has urgency, frequency, and
dysuria. Urine culture shows greater than 100,000 CFU/mL of E. coli. What is the most appropriate
treatment?
A. Nitrofurantoin 100 mg twice daily for 5 days
B. Ciprofloxacin 500 mg twice daily for 3 days
C. Amoxicillin 500 mg three times daily for 7 days
D. Trimethoprim-sulfamethoxazole DS twice daily for 14 days
6. A 31-year-old man presents with painless genital ulcers and bilateral inguinal lymphadenopathy. Darkfield
microscopy is positive for spirochetes. What is the most appropriate treatment?
A. Benzathine penicillin G 2.4 million units IM
B. Doxycycline 100 mg twice daily for 14 days
C. Ceftriaxone 250 mg IM
D. Azithromycin 1 g orally
7. A 26-year-old woman presents with anxiety, palpitations, and episodic tremors. She reports consuming 6
cups of coffee daily. She also takes a pseudoephedrine-containing decongestant. What is the most
appropriate initial management?
A. Reduce caffeine intake and discontinue decongestant
Page 3
, B. Start a beta-blocker
C. Start an SSRI for anxiety
D. Order a 24-hour urine catecholamines
8. A 44-year-old woman presents with periumbilical pain that has migrated to the right lower quadrant over 12
hours. She has nausea, vomiting, and low-grade fever. What is the most appropriate next step?
A. CT abdomen with contrast
B. Abdominal ultrasound
C. Appendectomy without imaging
D. Observation and repeat exam in 24 hours
9. A 25-year-old man presents with a purulent urethral discharge and dysuria. Gram stain shows neutrophils
with intracellular gram-negative diplococci. What is the most appropriate treatment?
A. Ceftriaxone 500 mg IM plus azithromycin 1 g orally
B. Doxycycline 100 mg twice daily for 7 days
C. Ciprofloxacin 500 mg orally
D. Metronidazole 2 g orally
10. A 32-year-old man presents with a rash on his palms and soles, generalized lymphadenopathy, and a healed
genital ulcer. VDRL is positive with a titer of 1:256. What is the stage of syphilis?
A. Secondary syphilis
B. Primary syphilis
C. Tertiary syphilis
D. Latent syphilis
11. A 46-year-old man presents with a 2-month history of blood-tinged sputum, weight loss, and a chronic cough.
He has smoked 1 pack per day for 30 years. Chest X-ray shows a central mass in the left hilum. What is the
most likely diagnosis?
A. Squamous cell carcinoma
B. Small cell lung cancer
C. Adenocarcinoma
D. Large cell carcinoma
12. A 73-year-old woman presents with confusion, fever, and cloudy urine with a foul odor. She is in a nursing
home. Urinalysis shows pyuria and bacteriuria. What is the most appropriate initial management?
A. Empiric antibiotics and hydration
B. Urine culture and observation
C. Foley catheter placement
D. Cranberry juice and increased fluids only
13. A 33-year-old woman presents with a 1-week history of watery diarrhea, abdominal cramps, and low-grade
fever after returning from a camping trip. Stool examination shows leukocytes and no blood. What is the most
likely causative organism?
A. Giardia lamblia
B. Shigella
C. Entamoeba histolytica
D. Clostridioides difficile
Page 4
Final Exam Prep
Test Bank
A+ Verified - Passing Score 80% - 6 Domains
Comprehensive 300-Question Practice Exam with Answer Key
2026-2027 Edition
For Educational Use Only | Not for Distribution
,Sections Covered
Section 1: Health Assessment (50 Questions)
Section 2: Pharmacology (50 Questions)
Section 3: Cardiovascular / Pulmonary (50 Questions)
Section 4: GI / Endocrine / Renal (50 Questions)
Section 5: Neuro / Musculoskeletal / Integumentary (50 Questions)
Section 6: Women's Health / OB-GYN (50 Questions)
Answer key is provided at the end of this document.
,1. A 19-year-old college student presents with sore throat, fever, and tender anterior cervical lymphadenopathy.
There is tonsillar exudate and no cough. What is the most appropriate next step?
A. Rapid strep antigen test
B. Start amoxicillin empirically
C. Monospot test
D. Throat culture only
2. A 36-year-old woman presents with a palpable breast mass that is firm, immobile, and painless.
Mammography shows a spiculated mass with microcalcifications. What is the most appropriate next step?
A. Core needle biopsy
B. Ultrasound-guided aspiration
C. Excisional biopsy
D. Repeat mammography in 6 months
3. A 74-year-old man with atrial fibrillation presents with acute onset of severe abdominal pain out of proportion
to exam findings. He has nausea and bloody diarrhea. What is the most likely diagnosis?
A. Acute mesenteric ischemia
B. Acute diverticulitis
C. Small bowel obstruction
D. Appendicitis
4. A 22-year-old woman presents with low-grade fever, malar rash, and arthritis in her hands and knees.
Laboratory studies show positive ANA, positive anti-dsDNA, and low complement levels. What is the
diagnosis?
A. Systemic lupus erythematosus
B. Rheumatoid arthritis
C. Mixed connective tissue disease
D. Dermatomyositis
5. A 41-year-old woman presents with recurrent urinary tract infections. She has urgency, frequency, and
dysuria. Urine culture shows greater than 100,000 CFU/mL of E. coli. What is the most appropriate
treatment?
A. Nitrofurantoin 100 mg twice daily for 5 days
B. Ciprofloxacin 500 mg twice daily for 3 days
C. Amoxicillin 500 mg three times daily for 7 days
D. Trimethoprim-sulfamethoxazole DS twice daily for 14 days
6. A 31-year-old man presents with painless genital ulcers and bilateral inguinal lymphadenopathy. Darkfield
microscopy is positive for spirochetes. What is the most appropriate treatment?
A. Benzathine penicillin G 2.4 million units IM
B. Doxycycline 100 mg twice daily for 14 days
C. Ceftriaxone 250 mg IM
D. Azithromycin 1 g orally
7. A 26-year-old woman presents with anxiety, palpitations, and episodic tremors. She reports consuming 6
cups of coffee daily. She also takes a pseudoephedrine-containing decongestant. What is the most
appropriate initial management?
A. Reduce caffeine intake and discontinue decongestant
Page 3
, B. Start a beta-blocker
C. Start an SSRI for anxiety
D. Order a 24-hour urine catecholamines
8. A 44-year-old woman presents with periumbilical pain that has migrated to the right lower quadrant over 12
hours. She has nausea, vomiting, and low-grade fever. What is the most appropriate next step?
A. CT abdomen with contrast
B. Abdominal ultrasound
C. Appendectomy without imaging
D. Observation and repeat exam in 24 hours
9. A 25-year-old man presents with a purulent urethral discharge and dysuria. Gram stain shows neutrophils
with intracellular gram-negative diplococci. What is the most appropriate treatment?
A. Ceftriaxone 500 mg IM plus azithromycin 1 g orally
B. Doxycycline 100 mg twice daily for 7 days
C. Ciprofloxacin 500 mg orally
D. Metronidazole 2 g orally
10. A 32-year-old man presents with a rash on his palms and soles, generalized lymphadenopathy, and a healed
genital ulcer. VDRL is positive with a titer of 1:256. What is the stage of syphilis?
A. Secondary syphilis
B. Primary syphilis
C. Tertiary syphilis
D. Latent syphilis
11. A 46-year-old man presents with a 2-month history of blood-tinged sputum, weight loss, and a chronic cough.
He has smoked 1 pack per day for 30 years. Chest X-ray shows a central mass in the left hilum. What is the
most likely diagnosis?
A. Squamous cell carcinoma
B. Small cell lung cancer
C. Adenocarcinoma
D. Large cell carcinoma
12. A 73-year-old woman presents with confusion, fever, and cloudy urine with a foul odor. She is in a nursing
home. Urinalysis shows pyuria and bacteriuria. What is the most appropriate initial management?
A. Empiric antibiotics and hydration
B. Urine culture and observation
C. Foley catheter placement
D. Cranberry juice and increased fluids only
13. A 33-year-old woman presents with a 1-week history of watery diarrhea, abdominal cramps, and low-grade
fever after returning from a camping trip. Stool examination shows leukocytes and no blood. What is the most
likely causative organism?
A. Giardia lamblia
B. Shigella
C. Entamoeba histolytica
D. Clostridioides difficile
Page 4
